{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:54:30Z","timestamp":1792169670203,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2506304"],"award-info":[{"award-number":["2023YFC2506304"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023YFS0032"],"award-info":[{"award-number":["2023YFS0032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201073"],"award-info":[{"award-number":["82201073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      LepR\u2010expressing cells (LepR\n                      <jats:sup>+<\/jats:sup>\n                      cells), a critical subpopulation of mesenchymal stem cells, have gained increasing attention in the last decade. LepR\n                      <jats:sup>+<\/jats:sup>\n                      cells have been found to play a crucial role in maintaining bone and periodontal homeostasis. This review summarizes current research advances focusing on the role of LepR\n                      <jats:sup>+<\/jats:sup>\n                      cells and their underlying regulatory molecular mechanisms in bones and periodontium, aiming to provide a better understanding of the therapeutic potential of this cell lineage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A literature review was conducted based on publications in PubMed over the past 20\u2009years, summarizing the research progress on LepR\n                      <jats:sup>+<\/jats:sup>\n                      cells in bone and periodontal tissues.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Current evidence revealed that LepR\n                      <jats:sup>+<\/jats:sup>\n                      cells possess the ability of self\u2010renewal and multilineage differentiation and are essential for bone turnover and periodontal tissue remodeling. In addition, LepR\n                      <jats:sup>+<\/jats:sup>\n                      cells participate in the processes of bone fracture healing and alveolar socket healing. Moreover, under pathological conditions such as osteoporosis, bone marrow fibrosis, and periodontitis, LepR\n                      <jats:sup>+<\/jats:sup>\n                      cells exhibit enhanced adipogenic or fibrogenic differentiation abilities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Therapeutic approaches targeting the cell fate of LepR\n                      <jats:sup>+<\/jats:sup>\n                      cells hold the potential to provide novel insights into bone\/periodontal repair and regeneration therapy.\n                    <\/jats:p>\n                  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