{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:05:53Z","timestamp":1775916353128,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To define tumor immunoarchitectural patterns (IPs) and characterize the immune profile in salivary gland mucoepidermoid carcinoma (MEC) toward assessing MEC prognostic significance and implications for immunotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study analyzed 41 MEC cases, evaluating the tumor IPs and tumor\u2010infiltrating lymphocyte (TIL) parameters by using whole\u2010slide imaging and AI\u2010assisted assessment. Immunohistochemistry of CD3 and CD8 markers was performed to assess key lymphocyte subpopulations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Immune\u2010rich (I\u2010rich) tumors were characterized by high TIL density and were associated with aggressive tumor behavior, particularly in histological high\u2010grade MEC, with a significant increase in TIL density observed in the inner invasive margin compartment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). I\u2010rich tumor cases were linked to poorer disease\u2010free survival (DFS) (Breslow\u2009=\u20094.686,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). Aggressive MEC cases displayed a highly heterogeneous TIL profile, however, no TIL patterns showed a significant impact on DFS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite the high immunogenicity suggested by the abundance of T lymphocytes, the protective role of CD8+ T lymphocytes was not prominent in MEC. I\u2010rich tumors appeared more aggressive and unfavorable MEC cases exhibited high heterogeneity in their TIL profiles. Interrogating the role of TILs in the inner invasive tumor margin may offer a new mechanistic understanding for future immunotherapy discovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15216","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T16:33:41Z","timestamp":1733762021000},"page":"1745-1756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunoarchitectural Pattern and Its Potential Prognostic Value in Mucoepidermoid Carcinoma"],"prefix":"10.1111","volume":"31","author":[{"given":"Vy Ngoc Thuy","family":"Tran","sequence":"first","affiliation":[{"name":"Oral Biology International Graduate Program, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"},{"name":"Center of Excellence and Innovation for Oral Health and Healthy Longevity, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Komkrit","family":"Ruangritchankul","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos G.","family":"Nikitakis","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine &amp; Pathology and Hospital Dentistry, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somponnat","family":"Sampattavanich","sequence":"additional","affiliation":[{"name":"Siriraj Center of Research Excellence for Systems Pharmacology, Department of Pharmacology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4230-4593","authenticated-orcid":false,"given":"Joao N.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Center of Excellence and Innovation for Oral Health and Healthy Longevity, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6416-773X","authenticated-orcid":false,"given":"Risa","family":"Chaisuparat","sequence":"additional","affiliation":[{"name":"Center of Excellence and Innovation for Oral Health and Healthy Longevity, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"},{"name":"Department of Oral Pathology, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A7960"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.12.016"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2013.03.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201017204\u20105"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100014\u2010x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655402_000028047"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010200107000\u201000001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/ott.S134589"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.10.044"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23256"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010014\u20103053\u2010z"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000429"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1163565"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41523\u2010022\u201000389\u2010y"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.101"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2703"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201006\u20104806"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.Ccr\u201015\u20101507"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/pap.0000000000000161"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698\u2010024\u201000501\u20104"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12488"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104931"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2019.09.004"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.3025"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201019\u20103758"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010021\u201006879\u20102"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058\u2010016\u20100737\u2010x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1043\/1543\u20102165\u2010133.11.1763"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.583333"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29120"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1889"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2019.2427"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601\u20100825.2002.02870.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201040888\u2010w"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0294236"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2020.10.012"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13488"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23249"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010023\u201001528\u2010y"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3862"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.15216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.15216","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.15216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T13:36:07Z","timestamp":1775914567000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.15216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,9]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/odi.15216"],"URL":"https:\/\/doi.org\/10.1111\/odi.15216","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ODI.15216\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15216\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15216\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15216\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15216\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15216\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15216\/v2\/review1","asserted-by":"object"}]},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,9]]},"assertion":[{"value":"2024-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}