{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:54:33Z","timestamp":1782320073428,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To systematically review the available literature reporting on genetic mutations leading to dento\u2010maxillofacial malformations in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>An electronic search was performed across Embase, PubMed, Web of Science, and Scopus databases up to May 2024, targeting all in\u00a0vivo studies on gene mutations causing dento\u2010maxillofacial deformities in mice. Studies reporting oral clefts were excluded. Data collected included genetic background, sex distribution, observation times, sample sizes, interventions, affected genes, zygosity, dento\u2010maxillofacial anomalies, and associated human syndromes. Risk of bias was evaluated using the SYRCLE tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 12,968 articles, 215 were included. The most common genetic background was C57BL6\/J (B6) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200983), and knock\u2010out was the most common intervention (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009142). A total of 172\u2009studies included homozygous mice. The five most studied genes were\n                      <jats:italic>Amelx, Bmp\u20102, Dspp, Enam, and Runx2<\/jats:italic>\n                      . Dento\u2010alveolar anomalies were more commonly reported (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009175) than skeletal (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200965). Skeletal anomalies were mostly related to micrognathia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914), agnathia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095), dysplasia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091), or reduced jaw size (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914). Risk of bias was moderate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Key genes\n                      <jats:italic>such as Amelx, Bmp\u20102, Dspp, Enam,<\/jats:italic>\n                      and\n                      <jats:italic>Runx2<\/jats:italic>\n                      implicated in dento\u2010maxillofacial abnormalities in mice, detailing the most prevalent skeletal and dento\u2010alveolar anomalies. These findings offer insights for developing gene therapy and diagnosing congenital malformations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15223","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T05:47:28Z","timestamp":1734414448000},"page":"1991-2000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic Mutations Leading to Dento\u2010Maxillofacial Abnormalities in Mice: A Systematic Review"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4235-1859","authenticated-orcid":false,"given":"Zuodong","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Oral Health Sciences\u2014Orthodontics, KU Leuven and Service of Dentistry University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achiel","family":"Van Bruwaene","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences\u2014Orthodontics, KU Leuven and Service of Dentistry University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Lievens","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences\u2014Orthodontics, KU Leuven and Service of Dentistry University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"De Laet","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences\u2014Orthodontics, KU Leuven and Service of Dentistry University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catia","family":"Attanasio","sequence":"additional","affiliation":[{"name":"Laboratory of Gene Regulation and Disease, Department of Human Genetics KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano Sim\u00f3n","family":"Pedano","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences\u2010Endodontics and BIOMAT\u2014Biomaterials Research Group, KU Leuven and Dentistry University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4710-255X","authenticated-orcid":false,"given":"Mar\u00eda","family":"Cadenas de Llano\u2010P\u00e9rula","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences\u2014Orthodontics, KU Leuven and Service of Dentistry University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336440"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.326900"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.445775"},{"key":"e_1_2_9_5_1","volume-title":"Hutchinson\u2010Gilford Progeria Syndrome","author":"Gordon L. 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