{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:05:39Z","timestamp":1775916339767,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the clinical manifestations of head and neck cancer in patients with Plummer\u2013Vinson syndrome (PVS) and to assess related oral comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Case reports covering head and neck cancer manifestations in patients diagnosed with PVS were included Studies were identified through seven main electronic databases (PubMed\/MEDLINE, EMBASE, Scopus, Web of Science, CINAHL, LILACS, and LIVIVO), and a search for gray literature was performed using ProQuest Dissertations and Theses and Google Scholar. Independent reviewers applied predefined eligibility criteria in a two\u2010phase selection process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of a total of 19,183 citations identified, seven met the inclusion criteria. Prevalent symptoms included dysphagia and esophageal webs, with atrophic glossitis and angular cheilitis being common oral manifestations. Most patients presented with long\u2010standing iron deficiency anemia. Head and neck cancers predominantly affected the pharynx and tongue borders, with younger age groups notably affected. The overall risk of bias attributable to the quality of the reports was assessed as \u201clow\u201d.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite the rarity of PVS\u2010related head and neck cancer, this review underscores its association, particularly in younger patients. A thorough examination of dysphagia and oral manifestations in PVS patients is crucial for early detection and prevention of head and neck cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15224","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T05:50:11Z","timestamp":1736142611000},"page":"1539-1545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Manifestations of Head and Neck Cancer in Patients With Plummer\u2013Vinson Syndrome: A Systematic Review"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1437-2871","authenticated-orcid":false,"given":"Brunno Santos de Freitas","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Stomatologic Sciences, School of Dentistry Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"},{"name":"University of An\u00e1polis  An\u00e1polis Goi\u00e1s Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora Peclat","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Stomatologic Sciences, School of Dentistry Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessah Carolyna de Andrade","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Stomatologic Sciences, School of Dentistry Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Rosa Santana","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Stomatologic Sciences, School of Dentistry Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5951-8280","authenticated-orcid":false,"given":"Omar","family":"Kujan","sequence":"additional","affiliation":[{"name":"UWA Dental School The University of Western Australia  Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Paula","family":"Yamamoto\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Stomatologic Sciences, School of Dentistry Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"},{"name":"University of An\u00e1polis  An\u00e1polis Goi\u00e1s Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0959\u20108049(01)00262\u20103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2006.06.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2006.06.013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108362200"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7175\/cmi.v14i1.1448"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000842"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.50.582.215"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5547.281"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.1999.889_r.x"},{"issue":"3","key":"e_1_2_9_11_1","first-page":"189","article-title":"Squamous Cell Carcinoma in the Tongue and Plummer\u2010Vinson Syndrome: A Case Report","volume":"15","author":"Donohue\u2010Cornejo A.","year":"2011","journal-title":"Revista Odontol\u00f3gica Mexicana"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200574"},{"key":"e_1_2_9_13_1","volume-title":"Global Cancer Observatory: Cancer Today","author":"Ferlay J.","year":"2024"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S127801"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102249.2004.02515.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119647"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007\u20101285\u201035\u2010410\u2010143"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2003.07438.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010020\u201000224\u20103"},{"issue":"11","key":"e_1_2_9_20_1","first-page":"3308","article-title":"Relationship of Plummer\u2010Vinson Disease to Cancer of the Upper Alimentary Tract in Sweden","volume":"35","author":"Larsson L. 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