{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:05:59Z","timestamp":1775916359640,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the sclerostin, \u03b2\u2010catenin, and tryptase expression in fibro\u2010osseous lesions (FOL) of the jaws.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>Immunohistochemistry analysis was performed for these proteins on FOL and non\u2010lesional bone. The sclerostin\u2010positive cells were scored from 0 (no expression) to 3 (high expression).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analyzed 46 FOL biopsies and selected 38 patients. Categorization showed 15 fibrous dysplasia (FD), eight juvenile trabecular ossifying fibroma (JTOF), two psammomatoid ossifying fibroma (PsOF), and 13 FOL. We found more sclerostin\u2010positive cells in fibrous tissue than in bone, showing a phenotype like mast cells with strong dot\u2010cytoplasmic positivity. The analysis of sclerostin\u2010positive cell lesions (scored as 2 and 3) showed also tryptase positivity in 80.9% of 21 biopsies. \u03b2\u2010catenin was diffusely expressed on the fibrous component, mostly with cytosol staining. Non\u2010lesional bone showed sclerostin expression in medullary spaces and a few osteocytes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sclerostin\u2010positive cells are mostly found in the fibrous tissue of FOL, and the tryptase mast cell marker was present in most of the lesions that were positive for sclerostin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15232","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T23:59:41Z","timestamp":1735603181000},"page":"1823-1830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interaction Between Sclerostin and Mast Cells in Fibro\u2010Osseous Lesions of the Jaws"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6357-0092","authenticated-orcid":false,"given":"Ri\u00e9li Elis","family":"Schulz","sequence":"first","affiliation":[{"name":"Department of Dentistry Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5503-3083","authenticated-orcid":false,"given":"Michel Calil","family":"Abr\u00e3o\u2010Neto","sequence":"additional","affiliation":[{"name":"School of Dentistry Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"},{"name":"Presidente Tancredo de Almeida Neves Universitary Center \u2013 UNIPTAN  S\u00e3o Jo\u00e3o Del Rey Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1437-8720","authenticated-orcid":false,"given":"Thiago Pires","family":"Claudio","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1656-6928","authenticated-orcid":false,"given":"Vin\u00edcius Gon\u00e7alves","family":"de Souza","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center Barretos Cancer Hospital  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-8771","authenticated-orcid":false,"given":"Elena Riet Correa","family":"Rivero","sequence":"additional","affiliation":[{"name":"Department of Pathology Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7547-660X","authenticated-orcid":false,"given":"Rog\u00e9rio Oliveira","family":"Gondak","sequence":"additional","affiliation":[{"name":"Department of Pathology Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9511-5078","authenticated-orcid":false,"given":"Gustavo Davi","family":"Rabelo","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.278.1.L193"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-013-9774-y"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14030357"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-22-0209"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2021.05.014"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12953"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-018-0971-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00058-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12531"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-019-00541-x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-018-0992-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00236"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-57303-z"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2808-0"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.687037"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13879"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-021-01404-7"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.11.024"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116367"}],"container-title":["Oral 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