{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T18:55:00Z","timestamp":1775156100169,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to explore differences in demographics, tumour characteristics and outcomes in oral squamous cell carcinoma (OSCC) patients with a history of non\u2010smoking, non\u2010drinking (NSND) versus smoking and\/or drinking (SD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Newly diagnosed OSCC patients undergoing curative surgical treatment were prospectively included in OncoLifeS, a data biobank. Cox regression analysis was performed yielding hazard ratios (HRs) and 95% confidence intervals (95%CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      185 patients were included, and 32.4% of patients were NSND; this group represented an older (69 vs. 64.4\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and more female\u2010dominated (66.7% vs. 44.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) population. NSND patients had more tongue tumours (68.3% vs. 46.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and few floor\u2010of\u2010mouth tumours (1.7% vs. 20.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Locoregional recurrence, overall survival and disease\u2010specific survival risk were similar between the NSND and SD patients. NSND patients had a higher second primary tumour risk compared to SD patients in the multivariable analysis (adjusted HR 3.92, 1.23\u201312.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NSND patients with OSCC have a distinct clinicopathological profile compared to SD patients, with a higher risk of second primary tumours after treatment. These differences in risk profiles should be considered in future OSCC management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15235","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T02:48:54Z","timestamp":1735613334000},"page":"2129-2138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Non\u2010smoking and Non\u2010drinking Oral Cancer Patients Are at Higher Risk of Second Primary Tumours"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1790-0032","authenticated-orcid":false,"given":"Pepijn J. P.","family":"van der Aa","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max J. H.","family":"Witjes","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"van der Vegt","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ed","family":"Schuuring","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koos","family":"Boeve","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grigory","family":"Sidorenkov","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geertruida H.","family":"de Bock","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiaan A. 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