{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:05:41Z","timestamp":1775916341807,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K09369"],"award-info":[{"award-number":["JP23K09369"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The effects of systemic inflammation on the temporomandibular joint (TMJ) are poorly understood. This study aimed to establish a mouse model to study the effects of systemic inflammation on the TMJ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>SKG mice, a BALB\/c strain with spontaneous onset of rheumatoid arthritis\u2010like symptoms due to a spontaneous point mutation (W163C) in the gene encoding the SH2 domain of ZAP\u201070, were treated with zymosan (\u03b2\u20101,3\u2010glucan). Synovitis, bone erosion, and cartilage damage in the TMJ were evaluated using established scores for animal models of inflammatory arthritis. Myeloperoxidase\u2010positive areas and numbers of tartrate\u2010resistant acid phosphatase (TRAP)\u2010positive cells were compared between naive and zymosan\u2010treated SKG mice. Correlations between TMJ inflammation scores and clinical scores for extremities were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were significant differences in TMJ inflammation scores, including synovitis, bone erosion, and cartilage damage, between naive and high\u2010dose zymosan\u2010treated mice. There were significant differences in myeloperoxidase\u2010positive areas and numbers of TRAP\u2010positive cells between naive and zymosan\u2010treated mice. There were significant correlations between TMJ inflammation scores and clinical scores for extremities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Systemic administration of zymosan efficiently induces TMJ inflammation in SKG mice. Zymosan\u2010treated SKG mice offer a useful tool to investigate the effects of systemic inflammation on the TMJ.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15242","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T02:34:32Z","timestamp":1735612472000},"page":"1831-1840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zymosan\u2010Treated\n                    <scp>SKG<\/scp>\n                    Mice: Assessing Effects of Systemic Inflammation on the Temporomandibular Joint"],"prefix":"10.1111","volume":"31","author":[{"given":"Kaito","family":"Uryu","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumasa","family":"Kakei","sequence":"additional","affiliation":[{"name":"Department of Oral and 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