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Programmed cell death and the regulation of its various pathways implicated in periodontal infection were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Multicellular organisms dispose of unnecessary or damaged cells via programmed cell death. Programmed cell death lies at the core of the balance of cell death and survival in pathological progress and infection. Periodontitis is a complex infectious disease involving virulence factors of periodontal pathogens and tightly regulated immune responses of the host. Different types of programmed cell death can play opposite roles in periodontitis or exert their action combinatorially.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The coordinated system of various programmed cell death pathways and the extensive crosstalk among them play a fundamental role in the pathophysiology of periodontitis. Illuminating the precise roles and mechanisms of programmed cell death in periodontitis could open up novel therapeutic approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15248","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T06:55:17Z","timestamp":1737615317000},"page":"1583-1594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Programmed Cell Death Tunes Periodontitis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2966-5633","authenticated-orcid":false,"given":"Yuejiao","family":"Xin","sequence":"first","affiliation":[{"name":"Department of Periodontics, Tianjin Stomatological Hospital, School of Medicine Nankai University  Tianjin China"},{"name":"Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction  Tianjin 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