{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:30:22Z","timestamp":1790573422564,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82020108010"],"award-info":[{"award-number":["82020108010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270976"],"award-info":[{"award-number":["82270976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82205200"],"award-info":[{"award-number":["82205200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The priming mechanism of adaptive immunity in oral mucositis remains unclarified. This study aimed to elucidate the mechanisms of oral lichen planus (OLP), with a specific focus on the role of inducible tertiary lymphoid structures (iTLSs) and stromal\u2010immune microenvironments within OLP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We employed single\u2010cell RNA sequencing and multiplex immunofluorescence staining to characterize the spatial characteristics and transcriptional signature of iTLSs in OLP. To investigate whether the presence of iTLSs influences the disease severity of OLP, we retrospectively collected clinical data from OLP patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Based on single\u2010cell resolution analysis, we identified distinct cellular compositions and fibroblast\u2010immune cells interactions within the iTLSs of OLP. We highlighted the critical role of CCL19\n                      <jats:sup>+<\/jats:sup>\n                      fibroblasts in T\u2010cell chemotaxis, promoting the development of iTLSs. Lymphotoxin was demonstrated to activate fibroblasts expressing CCL19. We revealed a significant correlation between the presence of iTLSs and increased severity of OLP, marked by more atrophic\u2010erosive forms and higher disease scores in patients with iTLSs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present research proposed the fibroblast\u2010immune cell interactions within iTLSs as essential factors in OLP's inflammatory milieu, indicating iTLSs as the priming structure of T\u2010cell immunity in the local oral mucosa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15266","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T01:54:46Z","timestamp":1739843686000},"page":"2191-2205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>CCL19<\/scp>\n                    <sup>+<\/sup>\n                    Fibroblasts Promote Tertiary Lymphoid Structure in Oral Lichen Planus: A Retrospective Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5951-5575","authenticated-orcid":false,"given":"Yi\u2010Rao","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, Shanghai Ninth People\u2019s Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology, College of Stomatology, Shanghai Research Institute of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3724-1783","authenticated-orcid":false,"given":"Lei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Shanghai Ninth People\u2019s Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology, College of Stomatology, Shanghai Research Institute of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases Shanghai Jiao Tong University  Shanghai China"},{"name":"Department of Second Dental Center, Shanghai Ninth People\u2019s Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1286-7974","authenticated-orcid":false,"given":"Xin\u2010Ke","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Shanghai Ninth People\u2019s Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology, College of Stomatology, Shanghai Research Institute of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Wen","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Shanghai Ninth People\u2019s Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology, College of Stomatology, Shanghai Research Institute of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0064-5461","authenticated-orcid":false,"given":"Ming\u2010Hua","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Shanghai Ninth People\u2019s Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Stomatology, the Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering and School of Life Sciences Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Zhe","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Oral Science and Translation Research, College of Dental Medicine Nova Southeastern University  Fort Lauderdale Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Developmental Biology and Molecular Medicine Fudan University  Shanghai 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of Stomatology, College of Stomatology, Shanghai Research Institute of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases Shanghai Jiao Tong University  Shanghai China"},{"name":"Shanghai Xin Hua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1008791"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"3","article-title":"Oral Lichen Planus: Clinical Features, Etiology, Treatment and Management; a Review of Literature","volume":"4","author":"Boorghani M.","year":"2010","journal-title":"Journal of Dental Research, Dental Clinics, Dental 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