{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T19:10:04Z","timestamp":1780773004530,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to compare the radiographic depth of the periodontal bone defect, as well as clinical and histological outcomes, between the proposed ligated defect model and the current non\u2010ligated defect model, which often heals spontaneously and fails to replicate the complexities of periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The proposed model combined osteotomy to create controlled periodontal bone defects (depth of 1.5\u2009mm) and ligature placement around the cervical region of the maxillary first molar to induce inflammation. Micro\u2010CT analysis, clinical examinations, histological evaluations, and quantitative PCR were conducted to assess defect morphology, healing, and inflammatory marker expression over 6\u2009weeks, compared with the non\u2010ligated defect group, sham surgery group, and control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Bone defect in the ligated defect group remained unhealed after surgery (1.525\u2009\u00b1\u20090.068\u2009mm in depth at 2\u2009weeks and 1.543\u2009\u00b1\u20090.082\u2009mm at 6\u2009weeks), with inflammatory cell infiltration and elevated expression of\n                      <jats:italic>IL\u20101\u03b2, IL\u20106,<\/jats:italic>\n                      and\n                      <jats:italic>TNF\u2010\u03b1<\/jats:italic>\n                      , contrasting with observed healing from 1.328\u2009\u00b1\u20090.075\u2009mm (2\u2009weeks) to 0.593\u2009\u00b1\u20090.118\u2009mm (6\u2009weeks) in the non\u2010ligated defect group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This model not only simulates the pathological features of periodontitis but also provides a reliable platform for testing innovative regenerative strategies and could lead to the development of specialized models for other periodontal conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15284","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T02:39:12Z","timestamp":1739846352000},"page":"2261-2272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Modified Intrabony Defect Model of Periodontitis in Rat"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4240-5124","authenticated-orcid":false,"given":"Pei","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology and National Center of Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Laboratory for Digital and Material Technology of Stomatology and Beijing Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010hao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology and National Center of Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Laboratory for Digital and Material Technology of Stomatology and Beijing Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology and National Center of Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Laboratory for Digital and Material Technology of Stomatology and Beijing Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology and National Center of Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Laboratory for Digital and Material Technology of Stomatology and Beijing Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0209-8622","authenticated-orcid":false,"given":"Qing\u2010xian","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology and National Center of Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Laboratory for Digital and Material Technology of Stomatology and Beijing Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5336-8712","authenticated-orcid":false,"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology and National Center of Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Laboratory for Digital and Material 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