{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:49:41Z","timestamp":1790347781416,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n \n To investigate the prevalence of\n BRAF<\/jats:italic>\n ,\n SMO<\/jats:italic>\n ,\n KRAS<\/jats:italic>\n ,\n HRAS<\/jats:italic>\n ,\n NRAS<\/jats:italic>\n ,\n FGRF2<\/jats:italic>\n , and\n CTNNB1<\/jats:italic>\n gene mutations in Chinese ameloblastoma (AM) patients and explore their associations with clinical characteristics.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n DNA was extracted from 89 formalin\u2010fixed paraffin\u2010embedded AM samples (9 unicystic and 80 conventional). PCR and Sanger sequencing were used to detect mutations, followed by statistical analysis to assess correlations between mutations and clinical variables.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n BRAF<\/jats:italic>\n V600E mutations were significantly prevalent, occurring in 92% (59\/64) of mandibular AMs compared to 40% (10\/25) in maxillary AMs.\n SMO<\/jats:italic>\n mutations were found in 20% (5\/25) of maxillary and 3.1% (2\/64) of mandibular AMs.\n FGFR2<\/jats:italic>\n mutations were detected in six maxillary and two mandibular AMs, while\n RAS<\/jats:italic>\n mutations were present in four maxillary and one mandibular AM. No detectable\n HRAS<\/jats:italic>\n ,\n NRAS(G12)<\/jats:italic>\n , or\n CTNNB1<\/jats:italic>\n mutations were observed.\n BRAF<\/jats:italic>\n mutations showed mutual exclusivity with\n SMO<\/jats:italic>\n and\n FGFR2<\/jats:italic>\n mutations.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The high prevalence of\n BRAF<\/jats:italic>\n V600E mutations, particularly in mandibular AMs, suggests its potential as a diagnostic and therapeutic target. Distinct mutation profiles between maxillary and mandibular AMs indicate molecular diversity. In\n BRAF<\/jats:italic>\n \u2010negative cases, alternative oncogenic pathways involving\n SMO<\/jats:italic>\n ,\n FGFR2<\/jats:italic>\n , and\n RAS<\/jats:italic>\n may be actionable targets, underscoring the need for personalized treatment approaches.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/odi.15286","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:36:04Z","timestamp":1741739764000},"page":"2215-2220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mutational Landscape of Ameloblastoma: Analysis of\n \n BRAF<\/i>\n <\/scp>\n and Other Key Mutations in Chinese Patients"],"prefix":"10.1111","volume":"31","author":[{"given":"Zhu","family":"You","sequence":"first","affiliation":[{"name":"Central Laboratory Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials Beijing China"},{"name":"Department of Oral and Maxillofacial Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Sima","sequence":"additional","affiliation":[{"name":"First Dental Center, School and Hospital of Stomatology Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefen","family":"Li","sequence":"additional","affiliation":[{"name":"Central Laboratory Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrui","family":"Feng","sequence":"additional","affiliation":[{"name":"Central Laboratory Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Du","sequence":"additional","affiliation":[{"name":"Central Laboratory Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Central Laboratory Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4571-3739","authenticated-orcid":false,"given":"Lisha","family":"Sun","sequence":"additional","affiliation":[{"name":"Central Laboratory Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01125-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1069"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2022.03.003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2020.12.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13401"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2023.10.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2021.740788"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00852-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2023.04.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0255-7"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2023.106651"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13278"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14855"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2986"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042238"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-021-01404-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002104"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12807"}],"container-title":["Oral 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