{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:05:42Z","timestamp":1775916342865,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Pulse granuloma (PG), or giant cell hyaline angiopathy, is an immune\u2010mediated reaction often following the implantation of plant\u2010derived food particles. PGs are primarily found in the oral cavity and gastrointestinal tract and may represent a histopathological pitfall, being mistaken for other granulomatous conditions or tumors. This study is the first to compare oral to extraoral PGs, aiming to clarify the \u201chyaline angiopathy\u201d seen in PGs by developing a detailed histochemical and immunohistochemical profile of oral and colonic PGs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A computer search of 135,972 surgical pathology cases was conducted. PG histopathological slides, along with demographic and clinical data, were reviewed. Stains including Congo red, Masson trichrome, PAS, and immunostains CD31, ERG, and D2\u201040 were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixteen cases (11 oral, 5 extraoral) were identified, ranging from 7 to 81\u2009years of age. Oral PGs were linked to odontogenic cysts, while extraoral PGs were associated with intestinal inflammation and perforation. Angiolymphatic marker expression was limited to the inflamed connective tissue surrounding PG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that PGs reflect a granulomatous response to edible components and support surgical excision. The absence of vascular markers indicates that the term \u201cangiopathy\u201d is misleading, proposing that these \u201cwormy\u201d structures are fibrocollagenous responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15287","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T02:38:59Z","timestamp":1739846339000},"page":"1816-1822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Demystifying \u201cHyaline Angiopathy\u201d of Pulse Granuloma in Oral and Extraoral Surgical Pathology"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5589-2585","authenticated-orcid":false,"given":"Felipe Fornias","family":"Sperandio","sequence":"first","affiliation":[{"name":"Oral Pathologist, Oral Medicine Specialist College of Dentistry, University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus","family":"de Castro Costa","sequence":"additional","affiliation":[{"name":"Bauru School of Dentistry University of S\u00e3o Paulo  Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Lara","family":"de Carli","sequence":"additional","affiliation":[{"name":"College of Dentistry Federal University of Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rani","family":"Kanthan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine College of Medicine, University of Saskatchewan  Saskatoon 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