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This study investigates the impact of dasatinib and quercetin (D\u2009+\u2009Q) treatment on senescent cells (SnCs), senescence\u2010associated secretory phenotype (SASP), and neutrophil infiltration in aged alveolar bone, aiming to develop new strategies for combating age\u2010related bone resorption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>C57BL\/6 mice (2 and 18\u2009months) were used to examine alveolar bone resorption, inflammaging, and neutrophil infiltration. Aged mice received D\u2009+\u2009Q treatment to assess therapeutic effects. Key measurements included cementoenamel junction to the alveolar bone crest (CEJ\u2010ABC) distance, periodontal ligament (PDL) thickness, osteometabolism markers, SnCs accumulation, SASP expression, and neutrophil infiltration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Aged alveolar bone showed increased CEJ\u2010ABC distance, atrophied periodontal ligament, and unbalanced osteometabolism, along with elevated SnCs, SASP, and neutrophils compared to young controls. D\u2009+\u2009Q treatment improved these conditions by reducing CEJ\u2010ABC distance, enhancing periodontal ligament health, and boosting bone metabolism. It also lowered the expression of SnCs, SASP, and neutrophil markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>D\u2009+\u2009Q treatment effectively mitigates alveolar bone aging by clearing SnCs, lowering SASP levels, and reducing neutrophil aggregation, presenting a novel approach for age\u2010related bone resorption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15291","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T11:42:30Z","timestamp":1741693350000},"page":"1800-1815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Dasatinib and Quercetin Mitigate Age\u2010Related Alveolar Bone Inflammaging and Neutrophil 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