{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:05:38Z","timestamp":1775916338754,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objects<\/jats:title>\n                    <jats:p>This retrospective study aimed to investigate the clinical characteristics and prognostic features of acinic cell carcinoma (AciCC) of the salivary gland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One Hundred Ninety\u2010nine cases of AciCC were retrospectively reviewed. Clinical characteristics and outcomes were systematically collected. Recurrence\u2010free survival, metastases\u2010free survival, and overall survival of patients with different clinical variables were compared using the Kaplan\u2013Meier method and Cox univariate regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 199 patients were included (70 men, 129 women; mean age, 44.57\u2009years). The parotid gland was most frequently affected (75.0%), and the majority of patients were asymptomatic (71.36%). Most patients underwent surgical treatment. Follow\u2010up data were available for 155 patients, with a mean duration of 78.42\u2009months. Local recurrence occurred in 11.6% of these patients, regional metastases in 6.5%, and distant metastases in 5.2%. Of the 10 patients with metastases, 4 died of AciCC. Poorer survival was significantly associated with age &gt;\u200940\u2009years, perineural invasion, neck dissection, and advanced stage (III\/IV). Recurrence and metastases were strongly associated with AciCC\u2010related mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Regular follow\u2010up and careful lymph node assessment are critical for patients over 40\u2009years, those with perineural invasion, advanced\u2010stage disease, recurrence, or metastases, as these factors are linked to poorer outcomes in AciCCs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15301","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:33:44Z","timestamp":1741739624000},"page":"1717-1725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Characteristics and Prognostic Factors of 199 Salivary Acinic Cell Carcinoma"],"prefix":"10.1111","volume":"31","author":[{"given":"Lijing","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Oral Pathology Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences (2019RU034)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4571-3739","authenticated-orcid":false,"given":"Lisha","family":"Sun","sequence":"additional","affiliation":[{"name":"Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences (2019RU034)  Beijing China"},{"name":"Central Laboratory Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5983-2985","authenticated-orcid":false,"given":"Tie\u2010jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences (2019RU034)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2016.08.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010020\u201005998\u20106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2023.02.020"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318242a5b0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15225456"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100150"},{"issue":"5","key":"e_1_2_8_8_1","first-page":"404","article-title":"Acinic\u2010Cell Adenocarcinoma of Major Salivary Glands; Report of 27 Cases","volume":"30","author":"Godwin J. 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