{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:01:42Z","timestamp":1784019702371,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to assess the expression of invadopodia\u2010related proteins in mucoepidermoid carcinoma and their influence on this tumor's invasiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Twenty\u2010seven mucoepidermoid carcinoma grading samples were evaluated for the expression of Tks4, Tks5, cortactin, and MT1\u2010MMP and compared to 10 control samples of normal\u2010looking salivary glands by immunohistochemistry. For in\u00a0vitro analysis, immunofluorescence identified the expression of invadopodia\u2010related proteins in the mucoepidermoid carcinoma cell line. Invadopodia formation and invasion assays were performed after silencing of Tks4 and Tks5 to evaluate invasiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The invadopodia\u2010related proteins were expressed significantly higher in mucoepidermoid carcinoma samples when compared to the control group. Positive expression of these proteins was identified in the mucoepidermoid carcinoma cell line. Knockdown of Tks4 and Tks5 reduced both gelatin degradation and invadopodia activity in mucoepidermoid carcinoma cell lines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that mucoepidermoid carcinoma behavior can be mediated by the expression of invadopodia\u2010related proteins. Tks4 and Tks5 play a role in the invasiveness of mucoepidermoid carcinoma, mediated by invadopodia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15312","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:45:28Z","timestamp":1741999528000},"page":"2427-2440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Invadopodia Related\u2010Proteins Expression in Mucoepidermoid Carcinoma"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2428-1199","authenticated-orcid":false,"given":"Felippe Jos\u00e9 Almeida","family":"Loureiro","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Par\u00e1  Bel\u00e9m Brazil"},{"name":"Department of Oral Diagnosis, Piracicaba Dental School State University of Campinas  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolyny Martins","family":"Balbinot","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Par\u00e1  Bel\u00e9m Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Sueli","family":"da Silva Kataoka","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Par\u00e1  Bel\u00e9m Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hellen Thais","family":"Fuzii","sequence":"additional","affiliation":[{"name":"Tropical Medicine Center Federal University of Par\u00e1  Bel\u00e9m Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio","family":"de Melo Alves J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Par\u00e1  Bel\u00e9m 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