{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:10Z","timestamp":1772160850156,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated the anti\u2010inflammatory and antioxidative effects of ginsenoside Rb3 on experimental periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Experimental periodontitis was established by ligating the maxillary first molars. After 21\u2009days of Rb3 treatment, rats were sacrificed for micro\u2010CT and H&amp;E staining analysis and serum assay. qPCR detected the expression of inflammatory genes. IF detected MAPKs pathway activation in periodontal tissues. The effects were determined using LPS\u2010induced RAW264.7 cells. Gene expression levels were determined by qPCR. Intracellular ROS generation was detected by DCFH\u2010DA staining and flow cytometry. WB detected the activation of signaling pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Rb3 inhibited oxidative stress in experimental periodontitis, showing reduced gingivitis and alveolar bone resorption on H&amp;E staining and micro\u2010CT, and reduced\n                      <jats:italic>iNOS<\/jats:italic>\n                      mRNA in rats. Colorimetric results showed that Rb3 increased serum SOD and GSH\u2010Px activities and decreased MDA levels in rats. IF analysis showed that Rb3 inhibited P38, ERK, and JNK activation. Rb3 pretreatment significantly decreased\n                      <jats:italic>iNOS<\/jats:italic>\n                      and\n                      <jats:italic>IL\u20106<\/jats:italic>\n                      mRNA expression and ROS in Raw264.7 cells. WB analysis demonstrated that Rb3 blocked the activation of P38 and ERK.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Rb3 inhibits the level of oxidative stress and attenuates gingivitis and alveolar bone resorption in rats via the MAPKs signaling pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15318","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T18:41:37Z","timestamp":1742841697000},"page":"2540-2550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ginsenoside Rb3 Inhibits Oxidative Stress and Alleviates Experimental Periodontitis in Rats"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1375-4394","authenticated-orcid":false,"given":"Xin","family":"Meng","sequence":"first","affiliation":[{"name":"School of Stomatology Shandong Second Medical University  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Affiliated Hospital of Shandong Second Medical University  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueying","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Stomatology Shandong Second Medical University  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honghai","family":"Ji","sequence":"additional","affiliation":[{"name":"School of Stomatology Shandong Second Medical University  Weifang China"},{"name":"Department of Stomatology Affiliated Hospital of Shandong Second Medical University  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minmin","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Stomatology Shandong Second Medical University  Weifang China"},{"name":"Department of Stomatology Affiliated Hospital of Shandong Second Medical University  Weifang 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