{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:36:46Z","timestamp":1793900206763,"version":"4.8.0"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the short\u2010term effects of non\u2010surgical periodontal treatment (NSPT) on clinical and hematological indices in stage III\/IV grade C periodontitis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 121 systemically healthy patients with generalized stage III\/IV, grade C periodontitis were enrolled. Clinical indices (plaque index, probing depth, bleeding index, attachment loss) and hematological biomarkers [white blood cell count (WBC), mean platelet volume (MPV), neutrophil count (NEUT), neutrophil percentage (NEUT%), lymphocyte percentage (LYM%)] were measured before and 6\u20138\u2009weeks after NSPT. Patients were divided into younger (\u2264\u200935\u2009years) and elder (&gt;\u200935\u2009years) groups, further stratified by systemic antibiotics usage. Analyses were performed using chi\u2010squared tests, paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests, and Pearson's correlation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      NSPT resulted in clinical indices improvement, as well as a reduction in WBC, NEUT, NEUT%, and an increase in MPV and LYM% in both groups. SRP\u2010with\u2010antibiotics subgroups showed more significant changes. SRP\u2010without\u2010antibiotics subgroups showed six significant correlations in both groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05); SRP\u2010with\u2010antibiotics subgroups showed 11 correlations in the younger and five in the elder group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NSPT improved clinical and hematological outcomes in stage III\/IV grade C periodontitis patients over 6\u20138\u2009weeks. Younger patients exhibited more significant changes than elder patients, especially in the SRP\u2010without\u2010antibiotics subgroup.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15340","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T07:24:46Z","timestamp":1744701886000},"page":"2608-2618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Non\u2010Surgical Treatment on Hematological Indices in Stage III\/IV Grade C Periodontitis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0205-5393","authenticated-orcid":false,"given":"Xiaoyuan","family":"Guan","sequence":"first","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology  Beijing People's Republic of China"},{"name":"National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases  Beijing People's Republic of China"},{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian\u2010e","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology  Beijing People's Republic of China"},{"name":"National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases  Beijing People's Republic of China"},{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases  Beijing People's Republic of China"},{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology  Beijing People's Republic of China"},{"name":"The Fourth Clinical Division Peking University School and Hospital of Stomatology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingling","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology  Beijing People's Republic of China"},{"name":"National Center of Stomatology &amp; 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