{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:05:27Z","timestamp":1791777927775,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Condylar fibrocartilage regeneration after injury has been hindered by its poor self\u2010repair capacity. Injection of parathyroid hormone (PTH) has been proven to effectively delay cartilage damage in osteoarthritis. In this study, we investigated the regulatory effect of PTH on the homeostasis of condylar fibrocartilage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>FCSCs were extracted and exposed to a high PTH environment from rats to analyze the transcriptional changes. The condyles of mice were cultured ex\u00a0vivo and exposed to high PTH to observe changes in cartilage. Parathyroidectomy induced PTH\u2010deficient rats were locally injected with PTH to observe its effects on cartilage homeostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>High PTH environment could promote chondrogenic differentiation of FCSCs early, while weakening at late phase. The ex\u00a0vivo culture of mouse condyle under PTH stimulation enhanced the proliferation of chondrocytes early, which were replaced by hypertrophic chondrocytes. The degradation of cartilage matrix also grew distinct under high PTH. PTH deficiency induced osteoarthritis\u2010like changes in rats, characterized by cartilage layers disorder, chondrocyte reduction, and matrix degradation. Exogenous PTH could reverse fibrocartilage degeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The maintenance of PTH homeostasis is crucial for maintaining the function of temporomandibular condylar FCSCs. Exogenous PTH can ameliorate the characteristics associated with rat temporomandibular joint osteoarthritis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15355","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T01:30:02Z","timestamp":1745890202000},"page":"3089-3102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigate the Regulatory Role of Parathyroid Hormone on Condylar Fibrocartilage Homeostasis"],"prefix":"10.1111","volume":"31","author":[{"given":"Yanjing","family":"Zhan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases Sichuan University  Chengdu China"},{"name":"Department of Orthognathic and TMJ Surgery, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu 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