{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:40:53Z","timestamp":1778524853225,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the roles of Parkinson disease protein 7 (PARK7) in the context of oral lichen planus (OLP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Real\u2010time PCR and western blot were performed to detect the expression of PARK7. Chromatin Immunoprecipitation (ChIP) and luciferase reporter assays were conducted to confirm the binding of p65 and NF\u2010\u03baB element in the promoter of the human\n                      <jats:italic>PARK7<\/jats:italic>\n                      gene. The Caspase 3 and NF\u2010\u03baB detection kits were used for Caspase 3 and NF\u2010\u03baB activities measurement. Co\u2010Immunoprecipitation (Co\u2010IP) was applied to test the protein\u2013protein interactions in HOKs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The levels of PARK7 were up\u2010regulated in the diseased oral keratinocytes derived from OLP patients compared to those from healthy donors. Mechanistically, the activated NF\u2010\u03baB pathway could increase\n                      <jats:italic>PARK7<\/jats:italic>\n                      gene transcription in human oral keratinocytes (HOKs). Moreover, PARK7 deletion facilitated cell apoptosis and NF\u2010\u03baB activation in HOKs under OLP conditions. Overexpression of PARK7 could suppress cell apoptosis and NF\u2010\u03baB activation in the OLP cell model. At the molecular level, PARK7 could interact with BAX and p65 to inhibit cell apoptosis and NF\u2010\u03baB activation in HOKs, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data indicate that PARK7 is required to protect epithelia against damage in oral lichen planus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15361","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T01:25:32Z","timestamp":1745544332000},"page":"3060-3068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>PARK7<\/scp>\n                    Is Required to Protect Epithelia Against Damage in Oral Lichen Planus"],"prefix":"10.1111","volume":"31","author":[{"given":"Yufeng","family":"Fan","sequence":"first","affiliation":[{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Shanxi Medical University School and Hospital of Stomatology  Taiyuan Shanxi China"},{"name":"Department of Endodontics Shanxi Medical University School and Hospital of Stomatology  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukai","family":"Hao","sequence":"additional","affiliation":[{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Shanxi Medical University School and Hospital of Stomatology  Taiyuan Shanxi China"},{"name":"Department of Endodontics Shanxi Medical University School and Hospital of Stomatology  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hainan Provincial Hospital of Skin Disease  Haikou Hainan China"},{"name":"Department of Dermatology Affiliated Dermatology Hospital of Hainan Medical University  Haikou Hainan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Shanxi Medical University School and Hospital of Stomatology  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6062-493X","authenticated-orcid":false,"given":"Xuejun","family":"Ge","sequence":"additional","affiliation":[{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Shanxi Medical University School and Hospital of Stomatology  Taiyuan Shanxi China"},{"name":"Department of Endodontics Shanxi Medical University School and Hospital of Stomatology  Taiyuan Shanxi 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