{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:39:38Z","timestamp":1791358778459,"version":"4.3.1"},"reference-count":52,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ30797"],"award-info":[{"award-number":["2023JJ30797"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801021"],"award-info":[{"award-number":["81801021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review aimed to evaluate the effects of bisphosphonates (BP) and denosumab on dental implants, including implant failure (IF), marginal bone loss (MBL), and medication\u2010related osteonecrosis of the jaw (MRONJ).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A literature search was conducted in four databases and OpenGrey. Studies examining IF\/MBL\/MBRONJ associated with BP or denosumab were included. ROBINS\u2010I was used to assess the risk of bias. Trial sequential analysis and the GRADE approach were used to examine the certainty of evidence. Statistical analyses were conducted using R\u00a0version\u00a04.3.1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010one studies were included. BP was associated with IF only at the implant level (RR 1.74; 95% CI: 1.10\u20132.75) but not at the patient level (RR 1.01; 95% CI: 0.35\u20132.91). The analysis of two studies indicated no significant correlation between BP and MBL (MD 0.05; 95% CI: \u22120.12 to 0.21). BP was associated with MRONJ (RR 3.45; 95% CI: 2.56\u20134.65), whereas denosumab showed no significant statistical correlation with MRONJ (RR 25.98; 95% CI: 0.31\u20132165.63).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with dental implants, the existing very low certainty level evidence suggests that BP intake may be associated with greater risks of IF and MRONJ but not with MBL, whereas it is currently unknown whether denosumab is associated with MRONJ.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15373","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T06:29:03Z","timestamp":1746512943000},"page":"2835-2847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Bisphosphonates and Denosumab on Dental Implants: A Systematic Review With Meta\u2010Analysis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2092-4705","authenticated-orcid":false,"given":"Linni","family":"Lin","sequence":"first","affiliation":[{"name":"Center of Stomatology The Second Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Ren","sequence":"additional","affiliation":[{"name":"Xiangya School of Stomatology Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7330-6647","authenticated-orcid":false,"given":"Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Stomatology The Second Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-2715","authenticated-orcid":false,"given":"Qianqian","family":"Yao","sequence":"additional","affiliation":[{"name":"Center of Stomatology The Second Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14135"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid\u2010joi\u2010D\u201014\u201000195"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752\u20108062.2009.00152.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12526"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13137"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010022\u201004609\u20104"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.qi.a35523"},{"issue":"6","key":"e_1_2_11_9_1","first-page":"E106","article-title":"Survival of Dental Implants Among Post\u2010Menopausal Female Dental School Patients Taking Oral Bisphosphonates: A Retrospective Study","volume":"32","author":"Famili P.","year":"2011","journal-title":"Compendium of Continuing Education in Dentistry (Jamesburg, NJ: 1995)"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.18\u20100236"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.09.019"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/1082\u2010989x.11.2.193"},{"issue":"3","key":"e_1_2_11_15_1","first-page":"349","article-title":"Safety of Oral Bisphosphonates: Controlled Studies on Alveolar Bone","volume":"21","author":"Jeffcoat M. 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