{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:11:23Z","timestamp":1791871883724,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify whether the classic desmoplastic ameloblastoma (DA) is an independent subtype of ameloblastoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010six classic DA and 28 hybrid DA cases were retrieved, and available clinical, radiological, and histopathological data were collected. DNA from microdissected tumor tissues were utilized for\n                      <jats:italic>BRAF V600E<\/jats:italic>\n                      ,\n                      <jats:italic>SMOL412F<\/jats:italic>\n                      , and\n                      <jats:italic>CTNNB1<\/jats:italic>\n                      mutation detection. Data of classic DA and hybrid DA were analyzed and compared with each other and with previous reports of conventional ameloblastoma (CA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      69.8% (60\/86) of classic DA occurred in the mandible, with the majority affecting the anterior\u2010premolar regions. They were characterized as osteolytic bone expansion (33.8\u2009\u00b1\u200912.8\u2009mm) with internal bone\/calcification (57\/58, 98.3%) in radiology. Genetically, classic DA exhibited a high incidence of\n                      <jats:italic>BRAF V600E<\/jats:italic>\n                      mutation (58\/62, 93.5%) but no\n                      <jats:italic>CTNNB1<\/jats:italic>\n                      and\n                      <jats:italic>SMO L412F<\/jats:italic>\n                      mutations. Hybrid DA exhibited similarities to CA in jawbone location, tumor size, and radiology. The recurrence rate of classic DA (9.2%) was lower than that of CA (25.8%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      High anterior\u2010premolar distribution, a mixture of osteolytic and internal high\u2010density shadows in radiology, smaller tumor size, compressed epithelium with abundant stroma and scattered bone, consistent mutation of\n                      <jats:italic>BRAF V600E<\/jats:italic>\n                      , and better prognosis all suggest that classic DA may be a distinct clinicopathological subtype of ameloblastoma.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15376","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:49:08Z","timestamp":1747187348000},"page":"2914-2925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Classic Desmoplastic Ameloblastoma: Should It Be a Distinct Subtype of Ameloblastoma?\u2014Based on Clinicopathological, Radiological, Immunohistochemical and Molecular Study of a Large Cohort"],"prefix":"10.1111","volume":"31","author":[{"given":"Xiaofeng","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Oral Pathology Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"National Center for Stomatology  Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology  Shanghai China"},{"name":"Shanghai 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