{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T20:28:32Z","timestamp":1786825712283,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["21JR7RA612"],"award-info":[{"award-number":["21JR7RA612"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Matrix metalloproteinase\u20108 (MMP\u20108) serves as a biomarker for periodontal diseases; numerous studies have demonstrated its diagnostic accuracy in detecting both periodontitis and gingivitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search was performed up to 25 March 2025. Observational studies investigating MMP\u20108's diagnostic potential for periodontal disease and gingivitis were included. Pooled sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) were calculated using Stata 15.1, with diagnostic accuracy measures reported as point estimates and 95% confidence intervals (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The meta\u2010analysis included 22 diagnostic studies encompassing 2492 participants. Pooled estimates demonstrated robust diagnostic performance of MMP\u20108 for periodontal disease, with sensitivity of 0.83 (95% CI: 0.78\u20130.87), specificity of 0.77 (95% CI: 0.71\u20130.83), and AUC of 0.87 (95% CI: 0.84\u20130.90). Subgroup analysis revealed superior accuracy of immunofluorometric assay (IFMA), showing higher sensitivity (0.88) and specificity (0.77) compared to enzyme\u2010linked immunosorbent assay (ELISA, sensitivity\/specificity\u2009=\u20090.84\/0.76) and point\u2010of\u2010care testing (POCT, sensitivity\/specificity\u2009=\u20090.73\/0.64). Biological sample comparisons identified gingival crevicular fluid as the optimal source, achieving significantly higher diagnostic accuracy (AUC\u2009=\u20090.91) than mouth rinse (AUC\u2009=\u20090.89) or saliva (AUC\u2009=\u20090.76).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings demonstrated that MMP\u20108 serves as a robust diagnostic biomarker for both periodontitis and gingivitis, with detection methods\u2014IFMA, ELISA, and POCT\u2014showing context\u2010dependent applicability across clinical settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15389","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T06:29:05Z","timestamp":1747981745000},"page":"2818-2834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Diagnostic Accuracy of Matrix Metalloproteinase\u20108 for Detecting Periodontal Disease: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"31","author":[{"given":"Dong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Stomatology\/Department of Infection Management Gansu Provincial Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Stomatology\/Department of Infection Management Gansu Provincial Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Urology\/Stomatology Peking Union Medical College Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Stomatology\/Department of Infection Management Gansu Provincial Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology\/Department of Infection Management Gansu Provincial Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Stomatology\/Department of Infection Management Gansu Provincial Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2753-3272","authenticated-orcid":false,"given":"Kangle","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Stomatology\/Department of Infection Management Gansu Provincial Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179421"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2018.05.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12479"},{"issue":"3","key":"e_1_2_10_5_1","first-page":"211","article-title":"Assessment of Wound Healing Using MMP\u20108 Levels in GCF of Diabetics With Chronic Periodontitis After Diode Laser Assisted Flap Surgery","volume":"31","author":"Banerjee K.","year":"2023","journal-title":"Acta Informatica Medica: AIM: Journal of the Society for Medical Informatics of Bosnia & Herzegovina: Casopis Drustva Za Medicinsku Informatiku 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