{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:00Z","timestamp":1772160840521,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023915","name":"Faculty of Dentistry, Chulalongkorn University","doi-asserted-by":"publisher","award":["10.13039\/50110023915"],"award-info":[{"award-number":["10.13039\/50110023915"]}],"id":[{"id":"10.13039\/501100023915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010724","name":"Health Systems Research Institute","doi-asserted-by":"publisher","award":["68\u2010032,68\u2010059"],"award-info":[{"award-number":["68\u2010032,68\u2010059"]}],"id":[{"id":"10.13039\/501100010724","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Lobodontia, a complex tooth disorder characterized by carnivore\u2010like dentition, presents unique clinical challenges. This study aimed to characterize the physical, mechanical, and ultrastructural properties of lobodontia teeth to inform precision treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included two extracted teeth (one from each lobodontia patient) and ten control teeth from healthy individuals. Clinical, radiographic, dental impression, and microstructural analyses were performed, including colorimetry, surface roughness, microCT, SEM, EDX, nanoindentation, and histology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lobodontia teeth exhibited a distinctive multitubercular occlusal morphology, with deep grooves and multiple cusps. Radiographs showed dens invaginatus and taurodontism. Compared to controls, lobodontia teeth had increased surface roughness and color deviations. Although mineral composition was similar, lobodontia teeth showed significantly reduced hardness, elastic modulus, enamel thickness, and a disrupted dentinoenamel junction with a pronounced gap between enamel and dentin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lobodontia teeth exhibit compromised structural integrity, including diminished hardness, elasticity, and enamel thickness, alongside a defective dentinoenamel junction. These characteristics increase the risk of biofilm retention, infection, and malocclusion, necessitating personalized care approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15390","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T02:21:06Z","timestamp":1748226066000},"page":"3115-3125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lobodontia\u2010Affected Teeth Exhibit Compromised Integrity and Enamel Defects: A Deep Phenotyping Study"],"prefix":"10.1111","volume":"31","author":[{"given":"Thanakorn","family":"Theerapanon","sequence":"first","affiliation":[{"name":"Interdisciplinary Program of Biomedical Sciences, Graduate School Chulalongkorn University  Bangkok Thailand"},{"name":"Center of Excellence in Precision Medicine and Digital Health, Center of Excellence in Genomics and Precision Dentistry, Geriatric Dentistry and Special Patients Care International Program, Department of Physiology, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narin","family":"Intarak","sequence":"additional","affiliation":[{"name":"Center of Excellence in Precision Medicine and Digital Health, Center of Excellence in Genomics and Precision Dentistry, Geriatric Dentistry and Special Patients Care International Program, Department of Physiology, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasiprapa","family":"Prommanee","sequence":"additional","affiliation":[{"name":"Center of Excellence in Precision Medicine and Digital Health, Center of Excellence in Genomics and Precision Dentistry, Geriatric Dentistry and Special Patients Care International Program, Department of Physiology, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"},{"name":"Clinical Research Center, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunisa","family":"Somkana","sequence":"additional","affiliation":[{"name":"Center of Excellence in Precision Medicine and Digital Health, Center of Excellence in Genomics and Precision Dentistry, Geriatric Dentistry and Special Patients Care International Program, Department of Physiology, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirinya","family":"Kulvitit","sequence":"additional","affiliation":[{"name":"Center of Excellence in Precision Medicine and Digital Health, Center of Excellence in Genomics and Precision Dentistry, Geriatric Dentistry and Special Patients Care International Program, Department of Physiology, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"},{"name":"Department of Operative Dentistry, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anucharte","family":"Srijunbarl","sequence":"additional","affiliation":[{"name":"Dental Materials R&amp;D Center, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Tagami","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"},{"name":"Department of Cariology and Operative Dentistry, Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0145-9801","authenticated-orcid":false,"given":"Thantrira","family":"Porntaveetus","sequence":"additional","affiliation":[{"name":"Center of Excellence in Precision Medicine and Digital Health, Center of Excellence in Genomics and Precision Dentistry, Geriatric Dentistry and Special Patients Care International Program, Department of Physiology, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"},{"name":"Clinic of General\u2010, Special Care and Geriatric Dentistry, Center for Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,25]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"215","article-title":"Lobodontia: The Unravelling of the Wolf Teeth","volume":"54","author":"Ather A.","year":"2013","journal-title":"Romanian Journal of Morphology and 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