{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:22:42Z","timestamp":1782256962427,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["Programcode"],"award-info":[{"award-number":["Programcode"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["2531,Projectcode"],"award-info":[{"award-number":["2531,Projectcode"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["121N189"],"award-info":[{"award-number":["121N189"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Ameloblastoma (ABL), a common odontogenic tumor in the maxillofacial region, presents primarily as unicystic (U\u2010ABL) and conventional (C\u2010ABL) variants. Despite shared epithelial features, their distinct biological behaviors may stem from interactions between connective tissue and epithelial cells. Vimentin 3 (VIM3), a truncated variant of Vimentin\u2010Full Length (VIMFL), exhibits unique biological properties. This study is the first to investigate VIM3 expression in ABLs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Formalin\u2010fixed paraffin\u2010embedded (FFPE) samples of C\u2010ABL (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930), U\u2010ABL (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930), and dental follicles (DF,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) were analyzed. Immunohistochemical evaluation of VIM3, VIMFL, WNT5a, and MTCO1 was performed, alongside qRT\u2010PCR for VIM3, VIMFL, WNT5a, ROR2, and miR\u2010498.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      VIM3 expression was significantly higher in C\u2010ABL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) compared to U\u2010ABL and DFs. VIMFL was absent in the epithelial components of all cases. C\u2010ABL showed significantly higher WNT5a (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and MTCO1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0327) expression. qRT\u2010PCR revealed significant differences in VIM3 and miR\u2010498 levels between U\u2010ABL and DFs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). No significant differences were found for WNT5a, VIMFL, or ROR2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study identifies VIM3 expression in ABLs, distinct from VIMFL, suggesting its potential as a biomarker. Additionally, mitochondrial dysfunction may play a role in ABL tumorigenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15396","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:44:51Z","timestamp":1748915091000},"page":"3081-3088","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Role of Vimentin 3 in Ameloblastomas: A Novel Tumor Biomarker"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0732-3617","authenticated-orcid":false,"given":"Sibel Elif","family":"Gultekin","sequence":"first","affiliation":[{"name":"Department of Oral Pathology Faculty of Dentistry, Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1499-7644","authenticated-orcid":false,"given":"Melanie","family":"von Brandenstein","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Urology Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5096-4279","authenticated-orcid":false,"given":"Emre","family":"Baris","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Faculty of Dentistry, Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9663-5454","authenticated-orcid":false,"given":"Ipek","family":"Atak Secen","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Faculty of Dentistry, Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4133-0319","authenticated-orcid":false,"given":"Leyla","family":"Arslan Bozdag","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Faculty of Dentistry, Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0171-7025","authenticated-orcid":false,"given":"Heike","family":"Goebel","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3419"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.5512"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.07.220"},{"key":"e_1_2_8_5_1","volume-title":"Pathology and Genetics of Head and Neck Tumours","author":"Barnes 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