{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:20:34Z","timestamp":1780546834668,"version":"3.54.1"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013254","name":"National College Students Innovation and Entrepreneurship Training Program","doi-asserted-by":"publisher","award":["202310062008"],"award-info":[{"award-number":["202310062008"]}],"id":[{"id":"10.13039\/501100013254","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Peri\u2010implantitis is a common dental complication characterized by inflammation of peri\u2010implant tissues and progressive bone loss. With the rise of antibiotic resistance, this study investigates the potential of antimicrobial peptides (AMPs), specifically KL\u201012, a novel peptide derived from cecropin B, as an alternative therapeutic strategy against\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      , a key pathogen in peri\u2010implantitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We evaluated the structural stability, antibacterial efficacy, and cytotoxicity of KL\u201012. Antibacterial activity was measured against\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>P.\u2009gingivalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      , while the peptide's mode of action was explored concerning its effect on the gingipain proteases essential for the bacterium's nutrient acquisition. Additionally, we assessed KL\u201012's impact on macrophage polarization and anti\u2010inflammatory responses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The findings revealed that KL\u201012 exhibited significant antibacterial activity against\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>P.\u2009gingivalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      and demonstrated potential as a specific inhibitor of gingipains. It was observed that KL\u201012 disrupts bacterial viability through mechanisms involving deformation and nutrient deprivation, rather than traditional pore formation. KL\u201012 effectively modulated macrophage polarization, promoting M2 differentiation and enhancing anti\u2010inflammatory responses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest that KL\u201012 functions as a dual\u2010action therapeutic agent, targeting both bacterial pathogens and inflammatory processes in the management of peri\u2010implantitis. Future studies will aim to clarify the molecular mechanisms underlying KL\u201012's antibacterial and immunomodulatory effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15401","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T02:14:46Z","timestamp":1749780886000},"page":"3154-3166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["KL\u201012 Peptide Targets Peri\u2010Implantitis via Dual Antibacterial and Immunomodulatory Effects"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5071-7994","authenticated-orcid":false,"given":"Jiahao","family":"Qin","sequence":"first","affiliation":[{"name":"School and Hospital of Stomatology Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwei","family":"Yang","sequence":"additional","affiliation":[{"name":"School and Hospital of 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