{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:14:16Z","timestamp":1778616856513,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007375","name":"Pr\u00f3-Reitoria de Pesquisa, Universidade Federal de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007375","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Oral melanocytic nevi (OMN) are histologically similar to skin nevi; however, they are much rarer and not always related to sun exposure. This study aimed to characterize the histopathological, immunohistochemical, and molecular features of OMN in sun\u2010exposed (vermilion lip) and sun\u2010protected (intraoral) regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Cross\u2010sectional study on 14 intraoral and 20 vermilion lip OMN. Hematoxylin\u2013eosin, immunohistochemistry for TRP2 and MiTF, and RT\u2010qPCR for TRP2 and MiTF were used to assess histopathology, protein, and mRNA expression, respectively. Statistical analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Intramucous and blue nevi are the most frequent histological subtypes. Intraoral lesions predominantly affect Brown or Black individuals (64.3%), presenting mostly as macules. Vermilion lip nevi affect White individuals (75%), with elevated lesions (30%). Histologically, intraoral nevi show asymmetric, lack theques formation and floret cells, and present no mitotic activity or pleomorphism, while vermilion nevi display pleomorphism, symmetry, theques formation, floret cells, and solar elastosis. TRP2 and MiTF protein and mRNA expression were upregulated in both groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), with no differences between them (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intraoral and vermilion lip nevi have distinct histopathological features, but similar TRP2 and MiTF protein and mRNA expression. This characterization may aid the histopathological diagnosis of OMN and distinction from other oral pigmentations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15404","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T01:19:59Z","timestamp":1749777599000},"page":"2906-2913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterization of Oral Melanocytic Nevi in Sun\u2010Exposed and Sun\u2010Protected Regions"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-1360","authenticated-orcid":false,"given":"Thalita Soares","family":"Tavares","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Surgery, School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7655-8666","authenticated-orcid":false,"given":"Adriana Aparecida Silva","family":"da Costa","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Surgery, School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4212-1172","authenticated-orcid":false,"given":"Marina Gon\u00e7alves","family":"Diniz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biological Science Institute Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4698-3992","authenticated-orcid":false,"given":"Daniela Pereira","family":"Meirelles","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Surgery, School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1496-4137","authenticated-orcid":false,"given":"Sandra Beatriz Chaves","family":"Tarqu\u00ednio","sequence":"additional","affiliation":[{"name":"Department of Semiology and Clinics, School of Dentistry Universidade Federal de Pelotas  Pelotas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6560-9536","authenticated-orcid":false,"given":"Ana Carolina Uchoa","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Department of Semiology and Clinics, School of Dentistry Universidade Federal de Pelotas  Pelotas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1678-9363","authenticated-orcid":false,"given":"Aline Cristina Batista Rodrigues","family":"Johann","sequence":"additional","affiliation":[{"name":"Department of Dentistry, School of Life Sciences Pontif\u00edcia Universidade Cat\u00f3lica Do Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-8009","authenticated-orcid":false,"given":"Ricardo Santiago","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Surgery, School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5134-3466","authenticated-orcid":false,"given":"Maria C\u00e1ssia Ferreira","family":"de Aguiar","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Surgery, School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9179-0145","authenticated-orcid":false,"given":"Patr\u00edcia Carlos","family":"Caldeira","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Surgery, School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais 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