{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T19:27:27Z","timestamp":1781983647048,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The pathogenesis of mandibular condylar hypoplasia has not been fully understood. Our previous studies provided evidence that Gli1\n                      <jats:sup>+<\/jats:sup>\n                      osteogenic progenitors contribute to condylar development. This study aimed to investigate the role of YAP in Gli1\n                      <jats:sup>+<\/jats:sup>\n                      cells during condylar development.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We generated\n                      <jats:italic>Gli1\u2010Cre<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>ERT2<\/jats:italic>\n                      <\/jats:sup>\n                      ;\n                      <jats:italic>Yap<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>fl\/fl<\/jats:italic>\n                      <\/jats:sup>\n                      mice, in which tamoxifen (TMX) was used to induce the deletion of\n                      <jats:italic>Yap<\/jats:italic>\n                      in Gli1\n                      <jats:sup>+<\/jats:sup>\n                      cells. CHIR injection was to activate \u03b2\u2010catenin signaling. Microscopic photography, Micro\u2010CT, hematoxylin\u2013eosin (H&amp;E) staining, immunofluorescence (IF) staining, Real\u2010time quantitative polymerase chain reaction (RT\u2010qPCR), tartrate\u2010resistant acid phosphatase (TRAP) staining and calcein\u2010alizarin red double labeling were conducted for analyses. Chromatin immunoprecipitation (ChIP) assay was used to investigate the molecular mechanism involved.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      YAP co\u2010localized with mandibular condylar Gli1\n                      <jats:sup>+<\/jats:sup>\n                      osteogenic progenitors. After induction,\n                      <jats:italic>Gli1\u2010Cre<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>ERT2<\/jats:italic>\n                      <\/jats:sup>\n                      ;\n                      <jats:italic>Yap<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>fl\/fl<\/jats:italic>\n                      <\/jats:sup>\n                      mice suffered from condylar hypoplasia characterized by reduced bone mass and impaired osteogenesis due to decreased cell proliferation. ChIP\u2010qPCR analysis, RT\u2010qPCR analysis, and immunofluorescence staining further proved that YAP could directly regulate the expression of \u03b2\u2010catenin. Functionally, pharmacological activation of \u03b2\u2010catenin signaling successfully alleviated condylar hypoplasia in\n                      <jats:italic>Gli1\u2010Cre<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>ERT2<\/jats:italic>\n                      <\/jats:sup>\n                      ;\n                      <jats:italic>Yap<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>fl\/fl<\/jats:italic>\n                      <\/jats:sup>\n                      mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our study demonstrated that the YAP\/\u03b2\u2010catenin axis mediated osteogenesis in Gli1\n                      <jats:sup>+<\/jats:sup>\n                      osteogenic progenitors during condylar development, which may provide a potential target for the treatment of condylar hypoplasia.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70006","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T15:03:54Z","timestamp":1750777434000},"page":"3383-3394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>YAP<\/scp>\n                    Deficiency in Gli1\n                    <sup>+<\/sup>\n                    Osteogenic Progenitors Leads to Condylar Hypoplasia via \u03b2\u2010Catenin Signaling"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7490-8712","authenticated-orcid":false,"given":"Yang","family":"Xiao","sequence":"first","affiliation":[{"name":"Center for TMD &amp; Orofacial Pain Peking University School and Hospital of Stomatology  Beijing China"},{"name":"Central Laboratory Peking University School and Hospital of Stomatology  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