{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:39:33Z","timestamp":1784201973497,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>A systematic review and network meta\u2010analysis were conducted to address the following research question: \u201cWhat is the most effective preventive treatment for reducing the risk of jaw osteonecrosis after tooth extraction in patients receiving medications associated with osteonecrosis?\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Only randomized clinical trials conducted in adults with a history of medication use associated with osteonecrosis of the jaw, who were treated with a preventive method to reduce the risk of osteonecrosis after tooth extraction, were included. Risk of bias and quality of evidence were assessed using the Cochrane Collaboration tool. Bayesian random\u2010effects mixed treatment comparison model was employed to compare all evaluated strategies: regenerative therapy, primary closure, secondary closure, epiperiosteal flap, and ozone infiltration. The network meta\u2010analysis results were presented as point estimates with 95% credible intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five randomized clinical trials conducted between 2012 and 2024 were included after applying the predetermined criteria. These studies evaluated various interventions, including platelet\u2010rich fibrin, platelet\u2010rich plasma, oxygen\u2013ozone therapy, and different surgical closure techniques. Bayesian network meta\u2010analysis demonstrated no conclusive evidence of superiority for any intervention over primary closure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>No preventive strategy demonstrated superiority in reducing the risk of medication\u2010related osteonecrosis of the jaw in patients undergoing tooth extraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>International Prospective Register of Systematic Reviews: CRD42024619828<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70015","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T03:43:18Z","timestamp":1751341398000},"page":"3260-3271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Preventive Treatments for Osteonecrosis of the Jaw: A Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-749X","authenticated-orcid":false,"given":"Lucas Nascimento","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, School of Dentistry University of Pernambuco (UPE)  Recife Brazil"},{"name":"Integrated Anatomic Pathology Center Oswaldo Cruz University Hospital  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raisa","family":"Severino\u2010Lazo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, School of Dentistry University of Pernambuco (UPE)  Recife Brazil"},{"name":"Integrated Anatomic Pathology Center Oswaldo Cruz University Hospital  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belmiro Cavalcanti do Egito","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry University of Pernambuco (UPE)  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra L\u00facia Dantas","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, School of Dentistry University of Pernambuco (UPE)  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne de Vasconcelos","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, School of Dentistry University of Pernambuco (UPE)  Recife Brazil"},{"name":"Integrated Anatomic Pathology Center Oswaldo Cruz University Hospital  Recife Brazil"},{"name":"Department of Oral and Maxillofacial Pathology, School of Dentistry University of Pernambuco (UPE)  Arcoverde Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000010664"},{"issue":"4","key":"e_1_2_9_3_1","first-page":"299","article-title":"Risk Factors for Osteonecrosis of the Jaws: A Case\u2010Control Study From the CONDOR Dental PBRN","volume":"130","author":"Barasch A.","year":"2013","journal-title":"Texas Dental Journal"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.02.024"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012432.pub2"},{"key":"e_1_2_9_6_1","volume-title":"Raccomandazioni Clinico\u2010Terapeutiche Sull'osteonecrosi Delle Ossa Mascellari (ONJ) Farmaco\u2010Relata e Sua Prevenzione","author":"Campisi G.","year":"2020"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18168432"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.15006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.20963"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708\u20108208.2011.00384.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.01.026"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2020.01.014"},{"issue":"9","key":"e_1_2_9_13_1","first-page":"1391","article-title":"Bisphosphonate\u2010Associated Osteonecrosis of the Jaw 2\u2009Years After Teeth Extractions: A Case Report Solved With Non\u2010Invasive Treatment","volume":"18","author":"G\u00f3mez\u2010Moreno G.","year":"2014","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2012.08.442"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_9_16_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.4","author":"Higgins J. P. T.","year":"2023"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14\u20102385"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104733.2008.00347.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787\u2010017\u20100962\u20106"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.07.068"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2011.02.059"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190802483778"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2011.07.004"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.03.009"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198\u2010012\u20102239\u20108"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2024.01.007"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010016\u20100384\u20104"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807\u20103107bor\u20102018.vol32.0010"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2020.02.006"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12912"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13556"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59050972"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70015","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.70015","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T06:44:21Z","timestamp":1773557061000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.70015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/odi.70015"],"URL":"https:\/\/doi.org\/10.1111\/odi.70015","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ODI.70015\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70015\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70015\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70015\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70015\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70015\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70015\/v1\/review2","asserted-by":"object"}]},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"2025-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}