{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T07:02:12Z","timestamp":1773558132678,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T00:00:00Z","timestamp":1752364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T00:00:00Z","timestamp":1752364800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This randomized, double\u2010blind, placebo\u2010controlled clinical trial evaluated the effect of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>L. reuteri<\/jats:italic>\n                      <\/jats:styled-content>\n                      administration on postsurgical wound healing, pain levels, and patient\u2010reported outcomes (PROs) following extraction of fully impacted teeth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients requiring surgical extractions were included and randomly allocated to either test (probiotic) or control group (placebo). Following oral hygiene procedures, patients began a daily probiotic\/placebo intake 7\u2009days before surgery until 14\u2009days after surgery. Follow\u2010up was performed at 3 (T3), 7 (T7), and 14 (T14) days postop. Wound healing, postoperative complications, pain, perceived functional impairment, and Oral Health Impact Profile\u201014 (OHIP\u201014) were registered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 128 patients (67 in the test group and 61 in the control group) were analyzed. Wound healing significantly improved in the test group at T3 and T7. Trismus was significantly milder in the test group at T3 and T14. No differences in pain were noted. The test group experienced reduced chewing impairment and difficulty in oral hygiene procedures, exhibited significantly lower scores of OHIP\u201014 at T14, and required a reduced number of anti\u2010inflammatory medications in the first 7\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Limosilactobacillus reuteri<\/jats:italic>\n                      administration improved wound healing, reduced the severity of trismus, and was associated with improved PROs following impacted tooth extractions.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial registration:<\/jats:bold>\n                      The study protocol was registered in a clinical trials database (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link>\n                      ) with registration number NCT04903925\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70026","type":"journal-article","created":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T19:19:00Z","timestamp":1752434340000},"page":"3482-3494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Limosilactobacillus reuteri<\/i>\n                    Improves Healing Following Fully Impacted Tooth Extractions: Randomized Clinical Trial"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4971-9361","authenticated-orcid":false,"given":"Chiara","family":"Cinquini","sequence":"first","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa Italy"},{"name":"Dental Biomaterials Research Unit (d\u2010BRU) University of Liege  Liege Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana","family":"Izzetti","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6077-6658","authenticated-orcid":false,"given":"Marco","family":"Nisi","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Gulia","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berta","family":"Garcia Mira","sequence":"additional","affiliation":[{"name":"Department of Stomatology University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Barone","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa 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