{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:29:17Z","timestamp":1786422557456,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Medication\u2010Related Osteonecrosis of the Jaw (MRONJ) is a severe adverse effect of antiresorptive and antiangiogenic treatment, primarily in osteoporotic and oncologic patients. The disease is characterized by persistent jawbone necrosis that results in significant impairment of the quality of life of involved patients. The aim of this study is to compare the radiographic characteristics of MRONJ between osteoporotic and oncologic patients and assess the differences based on treatment type, particularly bisphosphonates and denosumab (RANK\u2010L inhibitors).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of 152 MRONJ patients (41 osteoporotic, 111 oncologic) from Rabin\u2010Bilinson Medical Center (2014\u20132024) examined radiographic features\u2014lytic changes, sclerosis, periosteal reactions, sequestration, and periodontal ligament destruction\u2014using panoramic radiography, CBCT, and MDCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sclerosis was more frequent in osteoporotic patients compared to oncologic patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). No statistically significant differences were found in other radiographic features. Bisphosphonate\u2010induced MRONJ was more frequently accompanied by sclerosis compared to denosumab\u2010related cases in osteoporotic patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0318), while no significant differences were found in the oncologic group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most of the radiographic features of MRONJ were similar in osteoporotic and oncologic patients. However, sclerosis was more common in osteoporotic patients exposed to Bisphosphonates, which may be due to their prolonged exposure to antiresorptive drugs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70030","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T06:17:54Z","timestamp":1752560274000},"page":"1642-1651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Radiographic Analysis of\n                    <scp>MRONJ<\/scp>\n                    in Osteoporotic and Oncologic Patients on Bisphosphonates or Denosumab"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9441-4066","authenticated-orcid":false,"given":"Omar","family":"Ghanaiem","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, the Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Oral and Maxillofacial Surgery Rabin Medical Center  Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavriel","family":"Chaushu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, the Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Oral and Maxillofacial Surgery Rabin Medical Center  Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daya","family":"Masri","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, the Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Oral and Maxillofacial Surgery Rabin Medical Center  Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab888"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12093299"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-010-0907-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.08.015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-020-00093-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-010-0975-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)60752-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.5624\/isd.2020.50.4.273"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.03.050"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-57635-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2022.02.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr435"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-59500-x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06214-9"},{"key":"e_1_2_9_17_1","volume-title":"Frontiers of Oral and Maxillofacial Medicine","author":"Thomas J. 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