{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:44:02Z","timestamp":1775108642961,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T00:00:00Z","timestamp":1752364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T00:00:00Z","timestamp":1752364800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301129"],"award-info":[{"award-number":["82301129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the quality of adverse event (AE) reporting and identify factors associated with reporting quality in randomized controlled trials (RCTs) of temporomandibular disorders (TMDs) treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched MEDLINE, Cochrane Library (CENTRAL), and EMBASE for RCTs on TMD treatment. Trial characteristics and AE data were extracted, with specific AEs classified using System Organ Class (SOC) terminology. We assessed the reporting quality with the 16\u2010item CONSORT Harms 2022 checklist. Factors influencing reporting quality were analyzed using multiple linear regression and an artificial neural network (ANN) with SHapley Additive exPlanations (SHAP) interpretation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 79 RCTs analyzed, neurological symptoms (e.g., headache, dizziness) were the primary AEs. Only three checklist items were reported in over 50% of studies. The median reporting score percentage was 18.8% (IQR 26.7%). No significant differences in score percentages were observed across treatment modalities (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.565). We finally screened out five key factors linked to higher reporting quality, including non\u2010profit funding, combined efficacy\u2010safety endpoints, absence of international collaboration, European country location, and registration status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AE reporting quality in TMDs treatment RCTs remains suboptimal. Adherence to the most current CONSORT Harms guidelines is recommended to improve transparency and consistency in harms reporting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70032","type":"journal-article","created":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T19:19:36Z","timestamp":1752434376000},"page":"6-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reporting Quality of Adverse Events in Temporomandibular Disorders Treatment: A Systematic Review"],"prefix":"10.1111","volume":"32","author":[{"given":"Chen","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010hang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4906-2830","authenticated-orcid":false,"given":"Yun\u2010hao","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Southwest Medical University  Luzhou Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po\u2010kam","family":"Wo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0625-7021","authenticated-orcid":false,"given":"Ji Woon","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul National University School of Dentistry &amp; Dental Research Institute Seoul National University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2175-0970","authenticated-orcid":false,"given":"Xin","family":"Xiong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40510\u2010023\u201000457\u20104"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010045105"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2022.2115773"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe048225"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2023.12.004"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12140"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13692"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2014.12.023"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002127"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2024.101114"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003121"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102013\u2010003436"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010141\u201010\u2010200411160\u201000009"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.33"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102022\u2010073725"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/pts.0000000000000407"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748\u2010720X.2012.00649.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11030459"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj12060157"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13489"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1611"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112483"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.03.002"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102018\u2010024537"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874\u2010020\u201001167\u20109"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g6501"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43441\u2010022\u201000417\u2010w"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010020\u201003710\u2010w"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003277"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.70032","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T04:18:52Z","timestamp":1775103532000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.70032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,13]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/odi.70032"],"URL":"https:\/\/doi.org\/10.1111\/odi.70032","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,13]]},"assertion":[{"value":"2025-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}