{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:44:06Z","timestamp":1775108646218,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non\u2010syndromic cleft palate only (NSCPO) and non\u2010syndromic cleft lip with or without cleft palate (NSCL\/P) are distinct malformations with different or partially overlapping etiologies. While NSCL\/P has been extensively studied, NSCPO remains relatively understudied. Emerging evidence suggests that long noncoding RNAs (lncRNAs) contribute to craniofacial development, potentially by regulating apoptosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study investigated the role of\n                      <jats:italic>FENDRR<\/jats:italic>\n                      , a lncRNA previously found to be downregulated in NSCL\/P, in NSCPO pathogenesis.\n                      <jats:italic>FENDRR<\/jats:italic>\n                      expression in NSCPO tissues was analyzed via RT\u2010qPCR and fluorescence in\u00a0situ hybridization. Apoptosis in human embryonic palatal mesenchymal (HEPM) cells was assessed using Western blotting, flow cytometry, and TUNEL assays. Bioinformatics, methylation\u2010specific PCR, dual\u2010luciferase reporter assays, and RNA immunoprecipitation were employed to examine\n                      <jats:italic>FENDRR<\/jats:italic>\n                      's interaction with\n                      <jats:italic>MFN1<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>FENDRR<\/jats:italic>\n                      was significantly reduced in NSCPO tissues.\n                      <jats:italic>FENDRR<\/jats:italic>\n                      knockdown disrupted mitochondrial dynamics and activated mitochondrial apoptosis in HEPM cells. Mechanistically,\n                      <jats:italic>FENDRR<\/jats:italic>\n                      formed an RNA\u2013DNA triplex with the\n                      <jats:italic>MFN1<\/jats:italic>\n                      promoter, recruiting TET2 to promote\n                      <jats:italic>MFN1<\/jats:italic>\n                      transcription via promoter demethylation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>FENDRR<\/jats:italic>\n                      enhances\n                      <jats:italic>MFN1<\/jats:italic>\n                      expression, maintains mitochondrial fusion, and suppresses apoptosis in HEPM cells. This study provides novel insights into the regulatory role of lncRNAs in NSCPO pathogenesis and identifies\n                      <jats:italic>FENDRR<\/jats:italic>\n                      as a potential therapeutic target.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70035","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T19:00:06Z","timestamp":1753556406000},"page":"183-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>\n                      LncRNA\n                      <i>FENDRR<\/i>\n                    <\/scp>\n                    Inhibits Mitochondrial Apoptosis via\n                    <scp>TET2<\/scp>\n                    \u2010Mediated\n                    <scp>DNA<\/scp>\n                    Demethylation of\n                    <scp>\n                      <i>MFN1<\/i>\n                    <\/scp>\n                    in\n                    <scp>NSCPO<\/scp>"],"prefix":"10.1111","volume":"32","author":[{"given":"Caihong","family":"Wu","sequence":"first","affiliation":[{"name":"Stomatological Hospital Affiliated Suzhou Vocational Health College  Suzhou China"},{"name":"Department of Orthodontics The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haojie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zerui","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Orthodontics The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Orthodontics The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthodontics The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongyin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"State Key Laboratory Cultivation Base of 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Research Center of Stomatological Translational Medicine  Nanjing Jiangsu China"},{"name":"Savaid Stomatology School Hangzhou Medical College  Hangzhou China"},{"name":"Hangzhou Stamotological Hospital (Zijingang Campus)  Hangzhou 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