{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:49:50Z","timestamp":1793508590366,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS) are considered the most painful oral inflammatory diseases, with high global prevalence and significant impacts on patients' quality of life. In the last decades, researchers have been exploring mucoadhesive drug delivery systems (MDDS) to improve drugs safety and efficacy through optimized formulations for enhancing patients compliance while addressing the limitations of semisolid products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the clinical efficacy of different MDDS (e.g., tablets, films, and patches) in treating OLP or RAS by a revision of the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>According to PRISMA guidelines, the study assessed the remission of signs and symptoms in terms of decreasing burning sensation, pain severity, and lesion size. The protocol was registered on the PROSPERO database (CRD42024603173) and records identified by Medline\/PubMed\/Scopus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirteen observational studies involving humans affected by OLP or RAS were included. The absence of standardized therapies in terms of MDDS, drug, and dosing regimen was highlighted. All MDDS offered several benefits, including prolonged drug release, protection from mechanical irritation, and pain and inflammation reduction. MDDS improved patients' adherence by minimizing daily applications and systemic side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MDDS may represent a promising option for both OLP and RAS treatments, addressing key limitations of traditional formulations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70042","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T10:55:18Z","timestamp":1753268118000},"page":"25-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mucoadhesive Drug Delivery Systems for Oral Chronic Inflammatory Mucosal Diseases. The Future is Already Present. A Systematic Review"],"prefix":"10.1111","volume":"32","author":[{"given":"M. E.","family":"Mauceri","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche Universit\u00e0 degli Studi di Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-1841","authenticated-orcid":false,"given":"M.","family":"Coppini","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina di Precisione in Area Medica, Chirurgica e Critica (Me.Pre.C.C.) Universit\u00e0 degli Studi di Palermo  Palermo Italy"},{"name":"Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali Universit\u00e0 degli Studi di Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5186-1244","authenticated-orcid":false,"given":"V.","family":"De Caro","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche Universit\u00e0 degli Studi di Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3240-2704","authenticated-orcid":false,"given":"G.","family":"Di Prima","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche Universit\u00e0 degli Studi di Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4008-6502","authenticated-orcid":false,"given":"R.","family":"Mauceri","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina di Precisione in Area Medica, Chirurgica e Critica (Me.Pre.C.C.) Universit\u00e0 degli Studi di Palermo  Palermo Italy"},{"name":"Unit\u00e0 di Medicina Orale e Odontoiatria per Pazienti Fragili, Dipartimento di Riabilitazione, Fragilit\u00e0 e Continuit\u00e0 delle Cure Azienda Ospedaliera Universitaria di Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Panzarella","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina di Precisione in Area Medica, Chirurgica e Critica (Me.Pre.C.C.) Universit\u00e0 degli Studi di Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Giuliana","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina di Precisione in Area Medica, Chirurgica e Critica (Me.Pre.C.C.) 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