{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T01:37:14Z","timestamp":1781055434321,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate the histopathology of diabetic periodontal tissues, we examined periodontal disease in Torii\u2010\n                      <jats:italic>Lepr<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>fa<\/jats:italic>\n                      <\/jats:sup>\n                      (SDT\n                      <jats:italic>fa\/fa<\/jats:italic>\n                      ) rats, mimicking type 2 diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty 30\u2010week\u2010old male SDT\n                      <jats:italic>fa\/fa<\/jats:italic>\n                      rats and age\u2010matched Sprague\u2013Dawley (SD) rats were fixed, and the mandibular first molars and their periodontal tissues were histochemically examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SDT\n                      <jats:italic>fa\/fa<\/jats:italic>\n                      rats exhibited epithelial downgrowth in the previous region of interradicular\/interalveolar septa and periodontal spaces. Many osteoclasts and osteoblasts were present on the alveolar bone, indicating high bone turnover. Masses of bacteria were predominantly observed in the necrotic dental pulps and the cementum, where most cementocytic lacunae were empty. The cementum of the SDT\n                      <jats:italic>fa\/fa<\/jats:italic>\n                      rats showed a distinct immunolocalization of osteocalcin, osteopontin, and dentin matrix protein\u20101 compared with the SD rats, but did not show advanced glycation end products, which were instead detected in some blood vessels and interstitial fibrous tissues associated with the down\u2010growing epithelium.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      SDT\n                      <jats:italic>fa\/fa<\/jats:italic>\n                      rats exhibited necrosis of dental pulp and severe periodontitis featuring markedly diminished alveolar bone because of stimulated bone resorption and formation. In addition, dead cementum may serve as bacterial nests, leading to changes in the localization of cementum matrix proteins.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70079","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T05:30:08Z","timestamp":1756704608000},"page":"536-549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Histochemical Assessment of Cementum and Alveolar Bone in\n                    <scp>SDT<\/scp>\n                    <i>fa\/fa<\/i>\n                    Rat Mimicking Type\n                    <scp>II<\/scp>\n                    Diabetes"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0309-6637","authenticated-orcid":false,"given":"Tomoka","family":"Hasegawa","sequence":"first","affiliation":[{"name":"Ultrastructure of Hard Tissues, Faculty of Dental Medicine, Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mako","family":"Sakakibara","sequence":"additional","affiliation":[{"name":"Ultrastructure of Hard Tissues, Faculty of Dental Medicine, Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Ultrastructure of Hard Tissues, Faculty of Dental Medicine, Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Haraguchi\u2010Kitakamae","sequence":"additional","affiliation":[{"name":"Ultrastructure of Hard Tissues, Faculty of Dental Medicine, Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weisong","family":"Li","sequence":"additional","affiliation":[{"name":"Ultrastructure of Hard Tissues, Faculty of Dental Medicine, Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3506-1375","authenticated-orcid":false,"given":"Haoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Ultrastructure of Hard Tissues, Faculty of Dental Medicine, Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shi","sequence":"additional","affiliation":[{"name":"Ultrastructure of Hard Tissues, Faculty of Dental Medicine, Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Cui","sequence":"additional","affiliation":[{"name":"Ultrastructure of Hard Tissues, Faculty of Dental Medicine, Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Hongo","sequence":"additional","affiliation":[{"name":"Ultrastructure of Hard Tissues, Faculty of Dental Medicine, Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomaya","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Ultrastructure of Hard Tissues, Faculty of Dental Medicine, Hokkaido University  Sapporo Japan"},{"name":"Department of Dentistry Japan Ground Self\u2010Defense Force Camp  Shinmachi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Abe\u2010Takagi","sequence":"additional","affiliation":[{"name":"Ultrastructure of Hard Tissues, Faculty of Dental Medicine, Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhi","family":"Maruoka","sequence":"additional","affiliation":[{"name":"Ultrastructure of Hard Tissues, Faculty of Dental Medicine, Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Miyaji","sequence":"additional","affiliation":[{"name":"General Dentistry, Faculty of Dental Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9980-1382","authenticated-orcid":false,"given":"Minqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Bone Metabolism School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Shandong Key Laboratory of Oral Tissue Regeneration &amp; 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