{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:10:54Z","timestamp":1792519854712,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This review aimed to synthesize evidence on cardiovascular biomarkers associated with periodontitis, identified in biofluids such as blood, saliva, and gingival crevicular fluid (GCF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search of five databases was conducted to identify studies comparing cardiovascular biomarker levels in periodontitis and healthy individuals, up to 31 December 2024. Meta\u2010analysis included biomarkers from \u2265\u20092 studies per biofluid, with sensitivity analysis performed and evidence certainty assessed using the GRADE tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010six studies were included in the systematic review, with 31 eligible for meta\u2010analysis. Overall, 39 biomarkers were identified: 33 in blood, 14 in saliva, and 6 in GCF. A meta\u2010analysis was conducted for 12 blood biomarkers, of which high\u2010density lipoprotein (HDL) was significantly reduced, low\u2010density lipoprotein (LDL) was higher in periodontitis (though LDL lost significance on sensitivity analysis), and the oxidative stress index (OSI) was significantly associated with periodontitis. No significant differences were observed for C\u2010reactive protein (CRP), interleukin\u20101beta (IL\u20101\u00df), interleukin (IL)\u20106, N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT\u2010proBNP), monocyte chemoattractant protein\u20101 (MCP\u20101), and asymmetric dimethylarginine (ADMA). CRP was the only biomarker pooled for saliva and GCF, with no significant findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Reduced blood HDL and elevated OSI represent potential cardiovascular biomarkers for periodontitis, although the certainty of evidence remains low.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70084","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T05:46:24Z","timestamp":1756705584000},"page":"278-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardiovascular Biomarkers in Periodontitis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"32","author":[{"given":"Vandana","family":"Gupta","sequence":"first","affiliation":[{"name":"Division of Periodontics Centre for Dental Education &amp; Research, All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4340-3910","authenticated-orcid":false,"given":"Anika","family":"Dawar","sequence":"additional","affiliation":[{"name":"Division of Periodontics Centre for Dental Education &amp; 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