{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:06:57Z","timestamp":1791821217655,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the outcomes of combining carbon ion radiotherapy boost (CIRTb) with photons (Ph) or protons (PT) for locally advanced salivary gland and sinonasal cancers (SGCs and SNCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Sixty\u2010nine patients with SGCs and SNCs received CIRTb to high\u2010risk CTV and Ph or PT to low\u2010risk CTV (LR\u2010CTV) from October 2014 to September 2022. Two\u2010year local relapse\u2010free survival (LRFS) was analyzed with Kaplan\u2013Meier. Toxicity according to Common Terminology Criteria for Adverse Events v5. Variables affecting toxicities were analyzed with chi\u2010squared and Mann\u2013Whitney U tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients received a median CIRTb dose of 15\u2009Gy RBE, with 24 (35%) receiving Ph and 45 (65%) receiving PT. With a median follow\u2010up of 1805\u2009months, 2\u2010year LRFS achieved 89% (95% CI: 81\u201398). Female (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045) reported better 2\u2010year LRFS rates: 95% (95% CI: 87\u2013100) versus 84% (95% CI: 72\u201398). Acute and late G2+ toxicity were, respectively, 80% and 60%. Ph (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) and smaller LR\u2010CTV (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) reduced acute and late toxicities. No G4 late toxicity was reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CIRT combined with Ph or PT seems a valuable option for locally advanced SGCs and SNCs. Prospective studies are needed to select the best treatment combination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70086","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T05:05:13Z","timestamp":1757480713000},"page":"431-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>COMBINATORIC<\/scp>\n                    : Carbon Ion Boost With Photons or Protons in Salivary Gland and Sinonasal Cancers"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6865-9935","authenticated-orcid":false,"given":"Anna Maria","family":"Camarda","sequence":"first","affiliation":[{"name":"Clinical Department, Radiation Oncology Unit National Center for Oncological Hadrontherapy (CNAO)  Pavia 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Radiation Oncology Unit National Center for Oncological Hadrontherapy (CNAO)  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Franzetti","sequence":"additional","affiliation":[{"name":"Clinical Department, Radiation Oncology Unit National Center for Oncological Hadrontherapy (CNAO)  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Facchinetti","sequence":"additional","affiliation":[{"name":"Clinical Trials Center National Center for Oncological Hadrontherapy (CNAO)  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Serra","sequence":"additional","affiliation":[{"name":"Clinical Trials Center National Center for Oncological Hadrontherapy (CNAO)  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Tinelli","sequence":"additional","affiliation":[{"name":"Clinical Trials Center National Center for Oncological 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