{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T05:42:18Z","timestamp":1776145338244,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005009","name":"Stiftelsen Assar Gabrielssons Fond","doi-asserted-by":"publisher","award":["FB20\u201023"],"award-info":[{"award-number":["FB20\u201023"]}],"id":[{"id":"10.13039\/501100005009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005009","name":"Stiftelsen Assar Gabrielssons Fond","doi-asserted-by":"publisher","award":["FB21\u201055"],"award-info":[{"award-number":["FB21\u201055"]}],"id":[{"id":"10.13039\/501100005009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005301","name":"Svenska Tandl\u00e4kare-S\u00e4llskapet","doi-asserted-by":"publisher","award":["1468"],"award-info":[{"award-number":["1468"]}],"id":[{"id":"10.13039\/501100005301","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Oral complications may negatively influence outcomes of haematopoietic cell transplantation (HCT). A comprehensive view of oral symptoms and symptom burden post\u2010HCT is lacking. This study aimed to determine the prevalence, severity, and temporal relationships of oral symptoms and their impact on well\u2010being in the early post\u2010HCT phase. Effects of transplant type and conditioning intensity were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective multicentre observational study, adult HCT recipients were interviewed and completed questionnaires on oral symptoms and well\u2010being three times a week during hospitalisation early post\u2010HCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 194 patients, 177 (91.2%) reported oral symptoms. Dry mouth was the earliest and most common (80.9%) followed by oral pain (35.6%), thickening\/swollen mucosa (33.0%), and taste changes (30.9%). Symptom frequency peaked on days 6 to 11 post\u2010HCT and caused significant burden: 59.3% experienced moderate to severe distress and 53.6% reported moderate to severe impact on well\u2010being. Symptom prevalence was highest among patients who received allogeneic HCT with MAC and those who underwent autologous HCT. Overall, MAC regimens were associated with earlier and more frequent symptoms, greater distress and higher impact on well\u2010being during days 0 to 11 post\u2010HCT compared to reduced\/non\u2010myeloablative regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Oral symptoms are prevalent, burdensome and significantly impact well\u2010being early post\u2010HCT, underscoring the need for close monitoring and supportive oral care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70099","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T20:41:07Z","timestamp":1758228067000},"page":"569-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patient\u2010Reported Oral Symptoms and Their Impact on Well\u2010Being After Haematopoietic Cell Transplantation"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7377-4208","authenticated-orcid":false,"given":"Kristina","family":"Skallsj\u00f6","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0638-4335","authenticated-orcid":false,"given":"Michael T.","family":"Brennan","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine\/Oral &amp; Maxillofacial Surgery Atrium Health Carolinas Medical Center  Charlotte North Carolina USA"},{"name":"Department of Otolaryngology\/Head and Neck Surgery Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3088-1550","authenticated-orcid":false,"given":"Bengt","family":"Hass\u00e9us","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1162-7656","authenticated-orcid":false,"given":"Jenny","family":"\u00d6hman","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Clinical Pathology Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-8390","authenticated-orcid":false,"given":"Judith E.","family":"Raber\u2010Durlacher","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Academic Centre for Dentistry Amsterdam University of Amsterdam and VU University  Amsterdam the Netherlands"},{"name":"Department of Oral and Maxillofacial Surgery, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3036-7554","authenticated-orcid":false,"given":"Marie\u2010Charlotte D. N. J. M.","family":"Huysmans","sequence":"additional","affiliation":[{"name":"Department of Dentistry Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1291-2798","authenticated-orcid":false,"given":"Alexa M. G. A.","family":"Laheij","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Academic Centre for Dentistry Amsterdam University of Amsterdam and VU University  Amsterdam the Netherlands"},{"name":"Department of Oral and Maxillofacial Surgery, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4522-3705","authenticated-orcid":false,"given":"Stephanie J. M.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Dentistry Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1639-5281","authenticated-orcid":false,"given":"Allan J.","family":"Hovan","sequence":"additional","affiliation":[{"name":"Oral Oncology and Dentistry British Columbia Cancer  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8276-0510","authenticated-orcid":false,"given":"Karin","family":"Garming Legert","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine Karolinska Institutet  Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6658-3865","authenticated-orcid":false,"given":"Scott","family":"Isom","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science, Division of Public Health Sciences Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6183-3303","authenticated-orcid":false,"given":"David M.","family":"Kline","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science, Division of Public Health Sciences Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1801-2072","authenticated-orcid":false,"given":"Nicole M. 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