{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:16:47Z","timestamp":1789193807148,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral mucosal melanoma (OMM) is a rare, aggressive malignancy; however, prognostic factors for OMM remain poorly defined. This systematic review and meta\u2010analysis aimed to identify prognostic predictors that influence survival outcomes in OMM patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Web of Science, and Scopus were searched for case reports, case series, and retrospective observational studies involving patients with OMM. Data on demographics, tumor features, and survival were extracted. Meta\u2010analysis was performed using a random\u2010effects model. Study quality was assessed using Murad criteria and the JBI checklist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 16 studies comprising 1151 patients were included in the systematic review; five studies with 942 patients were included in the meta\u2010analysis. The pooled 5\u2010year survival proportion was 34% (95% CI: 24%\u201345%,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200987%). Key predictors of poor prognosis included tumor size &gt;\u20094\u2009cm, lymph node metastasis, and non\u2010palatal tumor location. Palatal lesions showed better survival (2\u2010year survival\u201485%). Treatment primarily involved surgical resection; adjuvant therapies had limited benefit. Neck dissection showed no consistent survival advantage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tumor size, lymph node involvement, and anatomical site are significant prognostic indicators in OMM. Standardized staging systems incorporating tumor burden and histopathologic markers are essential for improved prognostication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70105","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T08:09:25Z","timestamp":1759219765000},"page":"350-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prognostic Predictors of Oral Mucosal Melanoma\u2014A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"32","author":[{"given":"Sofia","family":"Sebastian","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha\u00a0University  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9233-8292","authenticated-orcid":false,"given":"Monal","family":"Yuwanati","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha\u00a0University  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5426-3506","authenticated-orcid":false,"given":"Pratibha","family":"Ramani","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha\u00a0University  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.jcrt_1682_23"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2020.37.350.27330"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1079\u20102104(97)90318\u20108"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/ccid.s372287"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2020.05.028"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.1072"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601\u20100825.2011.01841.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.07.018"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2018.09.s187"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100714.2008.00660.x"},{"key":"e_1_2_9_12_1","unstructured":"Garzino\u2010Demo P.2004. \u201cJournal of Cranio\u2010Maxillo\u2010Facial Surgery: Official Publication of the European Association for Cranio\u2010Maxillo\u2010Facial Surgery.\u201d32:251\u2013257."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2003.12.007"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2025.04.333"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.17477"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cl2.1230"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30152"},{"key":"e_1_2_9_18_1","volume-title":"StatPearls","author":"Heistein J. 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