{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:23:03Z","timestamp":1791616983131,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the prevalence and clinical profile of treatment\u2010related adverse events (TRAE) associated with: (1) botulinum toxin in the upper face; (2) hyaluronic acid fillers in the lower face and nasolabial folds; and (3) nonsurgical facelifts with absorbable threads.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Searches were conducted in five electronic databases and gray literature. Proportion meta\u2010analyses were performed to estimate the prevalence of TRAE for each type of aesthetic procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      42 studies were included. TRAEs were reported in 34.8% of included patients. The highest TRAEs prevalence was associated with hyaluronic acid fillers (63.0%, 95% CI: 35%\u201384%), followed by nonsurgical facelifts with absorbable threads (20.0%, 95% CI: 8%\u201341%) and botulinum toxin in the upper face (18.0%, 95% CI: 10%\u201332%). The most frequently reported TRAEs were swelling (22.4%) and pain (19.0%) for hyaluronic acid fillers; pain (31.5%) and bruising (23.4%) for nonsurgical facelifts with threads; and headache for botulinum toxins. Hyaluronic acid fillers accounted for 67.3% of all TRAEs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093729\/4971).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The overall prevalence of adverse events was low for botulinum toxin and thread lifts, but high for hyaluronic acid fillers. Future studies should report all adverse events, expected and not expected, detailing the number of patients affected, total events, onset and recovery times, severity, and provider category.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70109","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T05:00:02Z","timestamp":1759726802000},"page":"384-394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Adverse Events in Nonsurgical Facial Aesthetic Procedures: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8060-1823","authenticated-orcid":false,"given":"Vit\u00f3ria Maria Sousa","family":"Cruz","sequence":"first","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8890-8723","authenticated-orcid":false,"given":"Sebasti\u00e3o Silv\u00e9rio","family":"Sousa\u2010Neto","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7504-7597","authenticated-orcid":false,"given":"Caique Mariano","family":"Pedroso","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3265-2671","authenticated-orcid":false,"given":"Maria Eduarda","family":"P\u00e9rez\u2010de\u2010Oliveira","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0307-4991","authenticated-orcid":false,"given":"Ana Gabriela Costa","family":"Normando","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5236-8988","authenticated-orcid":false,"given":"Helen Kaline Farias","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4210-2684","authenticated-orcid":false,"given":"Rafael Tomaz","family":"Gomes","sequence":"additional","affiliation":[{"name":"Private Practice  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0127-7998","authenticated-orcid":false,"given":"Ana Carolina","family":"Prado\u2010Ribeiro","sequence":"additional","affiliation":[{"name":"Dental Oncology Service, Instituto Do C\u00e2ncer Do Estado de S\u00e3o Paulo (ICESP) Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4591-4645","authenticated-orcid":false,"given":"Danyel Elias","family":"da Cruz Perez","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"},{"name":"Department of Clinical and Preventive Dentistry Universidade Federal de Pernambuco (UFPE)  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1840-4911","authenticated-orcid":false,"given":"Pablo Agustin","family":"Vargas","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-6617","authenticated-orcid":false,"given":"Alan Roger","family":"Santos\u2010Silva","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534\u2010200002000\u201000050"},{"key":"e_1_2_12_3_1","unstructured":"Alabama Administrative Code.2024.\u201cAdministration of Botulinum Toxin and Similar Treatments by Dentists.\u201dAla Admin Code r. 270\u2010X\u20102\u2010.25. Board of Dental Examiners of Alabama.https:\/\/www.law.cornell.edu\/regulations\/alabama\/Ala\u2010Admin\u2010Code\u2010r\u2010270\u2010X\u20102\u2010.25."},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjae133"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.46658\/JBIMES-20-01"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.11.084"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjy042"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010022\u201003207\u20109"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000076504.79727.62"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31829e52a7"},{"key":"e_1_2_12_11_1","unstructured":"Centers for Disease Control and Prevention.2023.\u201cUnlicensed Injectable Botulinum Toxin and Dermal Fillers Reported to Cause Adverse Events in the United 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