{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:02:19Z","timestamp":1782478939310,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30901680"],"award-info":[{"award-number":["30901680"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n We aimed to investigate the clinicopathologic and molecular characteristics of conventional and Langerhans cell\u2010rich (LC\u2010rich) variants of Calcifying Epithelial Odontogenic Tumor (CEOT).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Fifteen patients, eight with conventional and seven with LC\u2010rich variants, were analyzed using clinical data, radiographic features, and histopathologic assessments. A 560\u2010gene cancer panel, utilizing Agilent probe hybrid capture technology, was employed for next\u2010generation sequencing (NGS) to detect genetic mutations. The\n EGFR<\/jats:italic>\n c.2369C>T (p.T790M) mutation was identified and further validated using droplet digital PCR (ddPCR).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Our findings revealed that conventional CEOT primarily occurred in the mandible, with 75% displaying the\n EGFR<\/jats:italic>\n c.2369C>T (p.T790M) mutation. Conversely, the LC\u2010rich variant was more prevalent in the maxilla, with 28.57% exhibiting the same mutation. Radiographic patterns showed distinct differences, with the LC\u2010rich variant demonstrating more aggressive clinical behavior.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The identification of\n EGFR<\/jats:italic>\n c.2369C>T (p.T790M) mutations in both variants underscores its significant role in CEOT pathogenesis and suggests potential implications for targeted therapies. This comprehensive analysis enhances our understanding of the molecular landscape of CEOT variants and highlights the necessity for tailored diagnostic and treatment strategies.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/odi.70111","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:32:10Z","timestamp":1760405530000},"page":"515-527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["EGFR<\/i>\n T790M<\/scp>\n Mutations in Conventional and Langerhans Cell\u2010Rich Variants of\n CEOT<\/scp>\n : Unveiling Molecular Differences and Clinical Implications"],"prefix":"10.1111","volume":"32","author":[{"given":"Wenyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology Peking University School and Hospital of Stomatology Beijing People's Republic of China"},{"name":"National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Xue","sequence":"additional","affiliation":[{"name":"National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing People's Republic of China"},{"name":"Department of Oral Pathology Peking University School and Hospital of Stomatology Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4571-3739","authenticated-orcid":false,"given":"Lisha","family":"Sun","sequence":"additional","affiliation":[{"name":"National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing People's Republic of China"},{"name":"Central Laboratory Peking University School and Hospital of Stomatology Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology Peking University School and Hospital of Stomatology Beijing People's Republic of China"},{"name":"National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-7-14"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-013-0490-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.08.023"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.jomfp_187_22"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-9-37"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312828"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2017.05.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.2587"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01079.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2401-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-010-0216-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2017-204813"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-019-01009-1"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27294"},{"key":"e_1_2_8_16_1","volume-title":"WHO Classification of Tumours Editorial Board. 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