{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:05:31Z","timestamp":1784001931989,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To delineate oral and genetic features of Asian epidermolysis bullosa (EB) patients in comparison to Western reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 2018\u20132023 review of 42\u2009EB patients (EBS: 9; DDEB: 9; RDEB: 20; JEB: 4) with confirmed mutations via whole\u2010exome sequencing; oral findings followed standardized assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 42 patients (EBS: 9; DDEB: 9; RDEB: 20; JEB: 4), statistically significant differences were observed in oral blistering frequency (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), microstomia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), ankyloglossia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), palatal rugae loss (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), vestibular obliteration (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and enamel hypoplasia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Decayed, missing, and filled teeth (DMFT) scores showed no significant differences across subtypes. RDEB patients experienced the most severe mucosal complications, while all JEB patients demonstrated enamel hypoplasia with a high caries burden. Observed genotype\u2013phenotype patterns included frequent blistering in EBS with KRT5 or KRT14 mutations and extensive enamel loss in JEB patients with LAMB3 premature termination codons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Oral phenotypes vary significantly by EB subtype and align with previously reported Western cohorts. RDEB and JEB patients require early, tailored dental management to address mucosal fragility or enamel defects. Oral care and transdisciplinary coordination are essential to improving function, nutrition, and long\u2010term outcomes in EB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70114","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:32:27Z","timestamp":1760405547000},"page":"1358-1365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral Manifestations in Different Subtypes of Hereditary Epidermolysis Bullosa: A Retrospective Case Series From an Asian Cohort"],"prefix":"10.1111","volume":"32","author":[{"given":"Meng\u2010Ling","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Lun","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Stomatology National Cheng Kung University Hospital, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin Chin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nutritional Services National Cheng Kung University Hospital, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Hsiung","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Urology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Kai","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"International Center for Wound Repair and Regeneration (iWRR) National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1487-9525","authenticated-orcid":false,"given":"Yu\u2010Fen","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Stomatology National Cheng Kung University Hospital, School of Dentistry &amp; Institute of Oral Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Chewing and Swallowing Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080573"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010020\u20100210\u20100"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18692"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2022.07.006"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.11.039"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00723.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.2473"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/978-3-662-63709-8_48","volume-title":"Braun\u2010Falco\u00b4 s Dermatology","author":"Has C.","year":"2022"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18921"},{"key":"e_1_2_12_11_1","volume-title":"The Prevalence and Impact of Oral Lesions on the Quality of Life in Persons With Epidermolysis Bullosa","author":"Holmes H. 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