{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:57:18Z","timestamp":1777633038710,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>TMJOA is a chronic degenerative joint disorder with multiple etiologies that significantly impair patients' quality of life. Autophagy and apoptosis are critical to the pathogenesis of TMJOA. Trehalose is a novel autophagy activator and has significant therapeutic efficacy in mitigating diseases. This study investigated trehalose's role and possible mechanisms in TMJOA evolution, both in\u00a0vitro and in\u00a0vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rat condylar chondrocytes were identified by toluidine blue and type I\/II collagen immunofluorescence staining. Methods such as CCK\u20108 assay and immunofluorescence were used to detect the protective effect of trehalose on interleukin\u20101\u03b2 (IL\u20101\u03b2)\u2010induced chondrocytes. Histological staining and other techniques were applied to evaluate its therapeutic effect on monosodium iodoacetate (MIA)\u2010induced TMJOA in rats and its underlying mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Trehalose can suppress IL\u20101\u03b2\u2010induced apoptosis in condylar chondrocytes by stimulating autophagy through the activation of AMP\u2010activated kinase (AMPK) and UNC51\u2010like kinase\u20101 (ULK1). The inhibition of the AMPK signaling pathway negated the preventive effect of trehalose on TMJOA. TMJOA rats treated with trehalose exhibited phosphorylation of the AMPK\/ULK1 pathway and activation of autophagy, accompanied by cartilage protection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates the potential of trehalose as a novel treatment agent to impede the evolution of TMJOA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70122","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:59:12Z","timestamp":1761130752000},"page":"809-821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trehalose Alleviates the Advancement of Temporomandibular Joint Osteoarthritis via Regulating the\n                    <scp>AMPK<\/scp>\n                    \/\n                    <scp>ULK1<\/scp>\n                    Autophagy Pathway"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3310-440X","authenticated-orcid":false,"given":"Jingjing","family":"Xu","sequence":"first","affiliation":[{"name":"School of Stomatology Lanzhou University  Lanzhou China"},{"name":"Key Lab of Stomatology of State Ethnic Affairs Commission Northwest Minzu University  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2350-5363","authenticated-orcid":false,"given":"Yanjiao","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Stomatology Lanzhou University  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8433-6248","authenticated-orcid":false,"given":"Siqi","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Stomatology Lanzhou University  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9856-3815","authenticated-orcid":false,"given":"Wanping","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Stomatology Lanzhou University  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-225X","authenticated-orcid":false,"given":"Hong","family":"Kang","sequence":"additional","affiliation":[{"name":"School of Stomatology Lanzhou University  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5364-3235","authenticated-orcid":false,"given":"Guangjie","family":"Bao","sequence":"additional","affiliation":[{"name":"Key Lab of Stomatology of State Ethnic Affairs Commission Northwest Minzu University  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22174"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31064-X"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207742"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S262022"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122146"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.01133"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28423"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7754360"},{"issue":"4","key":"e_1_2_9_10_1","article-title":"Interventions for Managing Temporomandibular Joint Osteoarthritis","volume":"2012","author":"Souza R. F.","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aac5472"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.608388"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01948-5"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.06.77"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199809)41:9<1632::AID-ART14>3.0.CO;2-A"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4542"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26583"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2023.105642"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0749-9"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09782"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109486"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114904"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345221100179"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2000.1988"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.109"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-024-04667-2"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27238624"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaf1937"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06639"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani12162093"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160920560"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.06.069"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4254"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10102772"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1535292"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2021.106112"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.463"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118043"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.453"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30333"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052700"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2022.0065"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2023.12237"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.02.029"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1606647"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01330-w"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14269"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.02.006"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01290"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43245"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.44051"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70122","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.70122","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:28:42Z","timestamp":1777436922000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.70122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,22]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/odi.70122"],"URL":"https:\/\/doi.org\/10.1111\/odi.70122","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ODI.70122\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70122\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70122\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70122\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70122\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70122\/v3\/decision1","asserted-by":"object"}]},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,22]]},"assertion":[{"value":"2025-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}