{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:01:01Z","timestamp":1777633261587,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771105"],"award-info":[{"award-number":["81771105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This research aims to investigate the remote regulatory role of plasma exosomal miR\u2010375\u20103p in diabetic periodontitis and to design a local drug\u2010loading material to retard periodontal tissue destruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A rat model of diabetic periodontitis was established by steel wire ligation and streptozocin (STZ) injection. The remote regulating effect of plasma exosomal miR\u2010375\u20103p was verified by polymerase chain reaction (PCR) technique and in\u00a0vivo fluorescence trafficking. Metal\u2013organic framework (MOF) biomaterials were synthesized by the solution precipitation method. The physicochemical properties, biological properties, and therapeutic effects of drug\u2010loading MOFs were evaluated through in\u00a0vivo and in\u00a0vitro experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In vivo fluorescence trafficking analysis demonstrated that plasma exosomal miR\u2010375\u20103p was transferred from peripheral blood to periodontal tissue. Overexpression of miR\u2010375\u20103p inhibits the osteogenic differentiation and migration of bone marrow stem cells (BMSCs). MiR\u2010375\u20103p antagomir could be successfully loaded into MOF nanoparticles and delivered into BMSCs, and miR\u2010375\u20103p antagomir\u2010loading MOFs alleviate tissue destruction in diabetic periodontitis rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This research disclosed the remote regulatory role of plasma exosomal miR\u2010375\u20103p in diabetic periodontitis, which partially contributes to the mechanism of diabetic periodontitis development. The miR\u2010375\u20103p antagomir\u2010loading MOF nanoparticles demonstrated acceptable biological properties and therapeutic capacity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70132","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T05:10:38Z","timestamp":1764220238000},"page":"840-851","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Promotion of Bone Remodeling in Diabetic Periodontitis by Blocking Plasma Exosomal miR\u2010375\u20103p"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9906-9221","authenticated-orcid":false,"given":"Hanxiao","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology Shanghai Jiao Tong University  Shanghai 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