{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:59:33Z","timestamp":1777633173158,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ameloblastoma is a benign odontogenic tumor characterized by local aggressiveness and high recurrence rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To identify and classify molecular biomarkers associated with its invasive behavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following PRISMA recommendations for Systematic Reviews, a comprehensive search was conducted in PubMed, Scopus, Web of Science, and gray literature for English\u2010language studies published between March 2020 and March 2025. Eligible studies included those using human tissues, retrospective case series, or in\u00a0vitro assays with experimental validation. Studies focused solely on clinical, radiological, or histopathological aspects were excluded. Risk of bias was assessed using the Joanna Briggs Institute checklist for case series and the QUIN tool for in\u00a0vitro studies. Data extraction was carried out independently by three reviewers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 34 studies met the inclusion criteria, identifying 70 biomarkers related to tumor invasion. These were categorized by biological function, with the most commonly reported involved in extracellular matrix degradation, epithelial\u2010mesenchymal transition, bone remodeling, cell proliferation, stemness, and the tumor microenvironment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings suggest that metalloproteinases, cytokines, and EMT\u2010related proteins are key drivers of invasion. These biomarkers may represent valuable therapeutic targets for developing innovative and less invasive treatment strategies. This review was registered in the Open Science Framework.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70133","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:07:32Z","timestamp":1761628052000},"page":"647-656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Molecular Markers of Tumor Invasion in Ameloblastoma: A Systematic Review"],"prefix":"10.1111","volume":"32","author":[{"given":"B\u00e1rbara","family":"Escobar\u2010Duarte","sequence":"first","affiliation":[{"name":"Facultad de Odontolog\u00eda Universidad Andres Bello  Sede de Vi\u00f1a del Mar Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javiera","family":"Hidalgo\u2010Valenzuela","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda Universidad Andres Bello  Sede de Vi\u00f1a del Mar Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constanza","family":"Mar\u00edn M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda y Ciencias de la Rehabilitaci\u00f3n Universidad San Sebasti\u00e1n  Puerto Montt Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2022.05.026"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.3437"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.31557\/apjcp.2020.21.11.3373"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807\u20103107bor\u20102022.vol36.0072"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201003484\u20105"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2012.07.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.22210"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14962"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.Ccr\u201014\u20101069"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2022.101233"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.12659\/msm.921863"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807\u20103107bor\u20102022.vol36.0071"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010022\u201001430\u2010z"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000\u2010023\u201001379\u20109"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201074693\u20107"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5235376"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.25145"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13237"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.09.021"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5814"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/abr.abr_131_21"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010019\u201001044\u2010y"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.12659\/msm.923491"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2020.07.001"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2021.104712"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.331"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4317"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.14349"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1411"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.11124\/jbisrir\u2010d\u201019\u201000099"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.670188"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/osi2.1193"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2022.03.014"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/20417314221140500"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/10520295.2020.1800819"},{"issue":"3","key":"e_1_2_9_37_1","first-page":"141","article-title":"Guidance for Conducting Systematic Scoping Reviews","volume":"13","author":"Peters M. D. J.","year":"2015","journal-title":"JBI Evidence Implementation"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010019\u201001072\u20108"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010024\u201001743\u20101"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.46547"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13175"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2022.05.019"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_659_18"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.labinv.2025.104237"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2986"},{"issue":"1","key":"e_1_2_9_46_1","first-page":"19","article-title":"Immunoexpression of BRAF, EGFR and CD10 in Ameloblastoma","volume":"44","author":"Tan C. C.","year":"2022","journal-title":"Malaysian Journal of Pathology"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12010077"},{"key":"e_1_2_9_48_1","volume-title":"Head and Neck Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2022"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.900108"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18083899"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374\u2010021\u201000671\u2010w"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.labinv.2022.100023"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14909"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.70133","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:29:48Z","timestamp":1777436988000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.70133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,27]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/odi.70133"],"URL":"https:\/\/doi.org\/10.1111\/odi.70133","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ODI.70133\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70133\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70133\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70133\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70133\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70133\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70133\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70133\/v2\/review1","asserted-by":"object"}]},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,27]]},"assertion":[{"value":"2025-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}