{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:57:09Z","timestamp":1777633029392,"version":"3.51.4"},"reference-count":78,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["112\u2010S0016"],"award-info":[{"award-number":["112\u2010S0016"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["113\u2010S0018"],"award-info":[{"award-number":["113\u2010S0018"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["111\u2010S0140"],"award-info":[{"award-number":["111\u2010S0140"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["112\u2010S004"],"award-info":[{"award-number":["112\u2010S004"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["112\u2010N0015"],"award-info":[{"award-number":["112\u2010N0015"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Hypercholesterolemia may exacerbate chronic periodontitis (CP) but the mechanism is uncertain. 27\u2010Hydroxycholesterol (27HC) is metabolized from cholesterol through the action of cytochrome P450 27A1 (CYP27A1) and may participate in diseases associated with high cholesterol. This study aimed to examine the pro\u2010inflammatory effects of 27HC, its role in hypercholesterolemia\u2010aggravated CP, and the therapeutic action of felodipine, an inhibitor of CYP27A1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>J774 murine macrophages were used. The levels of cholesterol, 27HC, inducible nitric oxide synthase (iNOS), cyclooxygenase\u20102 (COX\u20102), and CC chemokine ligand 2 (CCL2) were measured. Ligature\u2010induced periodontitis was established in male rats fed with a normal diet (ND) or a high\u2010fat\/high\u2010cholesterol diet (HFHCD). Disease progression was evaluated by micro\u2010computed tomography, histology, and immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cholesterol enhanced the production of 27HC in macrophages, which promoted the expressions of iNOS, COX\u20102 and CCL2. HFHCD rats had hypercholesterolemia, higher serum and gingival 27HC, and more advanced periodontitis compared to ND rats. Felodipine suppressed cholesterol\u2010induced 27HC production in macrophages. Felodipine treatment did not affect serum cholesterol but significantly decreased serum and gingival 27HC and alleviated ligature\u2010induced periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data support the importance of 27HC in mediating hypercholesterolemia\u2013aggravated periodontitis. Inhibiting 27HC production may have therapeutic value in periodontitis or other inflammatory diseases exacerbated by high cholesterol.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70140","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T04:12:04Z","timestamp":1762402324000},"page":"873-885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Felodipine Allays High Cholesterol\u2013Aggravated Periodontitis via Attenuating 27\u2010Hydroxycholesterol"],"prefix":"10.1111","volume":"32","author":[{"given":"Hung\u2010Ying","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Dentistry National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sze\u2010Kwan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dentistry National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Dentistry, School of Dentistry, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Ning","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dentistry, School of Dentistry, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Heng","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Dentistry National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Dentistry, School of Dentistry, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Yuan","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Dentistry National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Dentistry, School of Dentistry, College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"College of Bio\u2010Resources and Agriculture National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Tung","family":"Shun","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Pathology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4674-4892","authenticated-orcid":false,"given":"Shih\u2010Jung","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Dentistry National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Dentistry, School of Dentistry, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang\u2010Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dentistry National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Dentistry, School of Dentistry, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3434-9094","authenticated-orcid":false,"given":"Han\u2010Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dentistry National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Dentistry, School of Dentistry, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12072021"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601\u20100825.2011.01893.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2016.10.018"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.16\u20100480"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00330"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.42.26253"},{"key":"e_1_2_10_8_1","first-page":"65","article-title":"Relationship Between Cholesterol and Triglyceride Blood Values and Periodontal Parameters in Patients of Mashhad Health Center","volume":"74","author":"Banihashemrad S. 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