{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:29:17Z","timestamp":1786422557433,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170971"],"award-info":[{"award-number":["82170971"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373187"],"award-info":[{"award-number":["82373187"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001060"],"award-info":[{"award-number":["82001060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Th17 cells play a critical role in alveolar bone loss, which is closely associated with osteoclast maturation during periodontitis. Previous studies have established that periodontal ligament cells (PDLCs) are a significant source of receptor activator of nuclear factor\u2010\u03baB ligand (RANKL), a pivotal osteoclast\u2010inducing cytokine. However, the mechanisms by which IL\u201017A promotes osteoclast activation via the PDL\u2010mediated pathways are poorly understood. This study investigates how IL\u201017A promotes RANKL production in PDLCs and evaluates the therapeutic potential of targeting the JAK\/STAT3 pathway in periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A ligature\u2010induced periodontitis (LIP) model was established and alveolar bone loss was assessed using micro\u2010CT and TRAP staining. The molecular mechanisms were investigated using bioinformatic analysis, western blotting, and immunohistochemistry. The efficacy of anti\u2010IL\u201017A (\u03b1IL\u201017A) and tofacitinib in inhibiting alveolar bone loss was evaluated through intraperitoneal injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>RANKL was predominantly expressed in the PDL during periodontitis. IL\u201017A enhanced osteoclast activity in RAW264.7 cells co\u2010cultured with PDLCs. IL\u201017A upregulated RANKL expression in PDLCs through STAT3 activation. Tofacitinib significantly inhibited alveolar bone loss by suppressing Th17 cell differentiation and osteoclast activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IL\u201017A promoted RANKL expression through JAK\/STAT3 activation in PDLCs. Tofacitinib, a clinically available JAK inhibitor, significantly attenuated alveolar bone loss in periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70154","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T04:55:06Z","timestamp":1764219306000},"page":"1652-1664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Th17\/IL\u201017A Drives Alveolar Bone Loss via the JAK\/STAT3\u2010RANKL Axis in the Periodontal Ligament"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4482-8403","authenticated-orcid":false,"given":"Die","family":"Lv","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuge","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; 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Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Xia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4903-1054","authenticated-orcid":false,"given":"Jiao","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianming","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"Department of Prosthodontics, National Clinical Research Center for Oral Diseases, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; 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