{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:05:55Z","timestamp":1784001955774,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Actinic cheilitis (AC) is a sun\u2010related oral potentially malignant disorder with no established optimal treatment. This systematic review aimed to evaluate the therapeutic efficacy of available treatments for AC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Randomized Clinical Trials (RCTs) comparing AC treatments with placebo or other interventions were included. In February 2025, a literature search was conducted in PubMed, Cochrane Central, SciELO, ClinicalTrials.gov, Scopus, and Web of Science. Risk of bias was assessed using the RoB2 tool. A qualitative synthesis was performed for each clinical outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight RCTs, involving 230 participants, were included. Treatments assessed included daylight or conventional photodynamic therapy (PDT) with or without methyl aminolevulinate (MAL), imiquimod, and CO\n                      <jats:sub>2<\/jats:sub>\n                      laser, among others. The highest 3\u2010month clearance rates were observed with MAL plus indoor daylight PDT, CO\n                      <jats:sub>2<\/jats:sub>\n                      laser, and electrodessication. At 6\u2009months, the CO\n                      <jats:sub>2<\/jats:sub>\n                      laser remained most effective. Limitations include five trials with a high risk of bias and the inability to perform meta\u2010analysis due to outcome measures heterogeneity and lack of standardized RCTs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Due to limitations, the most effective AC treatment remains undetermined. Future research must improve methodology, assess standardized therapies, and include long\u2010term follow\u2010up to assess recurrences and malignant transformation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>PROSPERO: CRD42024561899<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70162","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T04:20:13Z","timestamp":1764735613000},"page":"1226-1236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interventions for Treating Actinic Cheilitis: A Systematic Review"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5241-4553","authenticated-orcid":false,"given":"Alejandra","family":"Fern\u00e1ndez Herranz","sequence":"first","affiliation":[{"name":"ORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Gonz\u00e1lez\u2010Serrano","sequence":"additional","affiliation":[{"name":"ORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5080-5921","authenticated-orcid":false,"given":"Vito Carlo Alberto","family":"Caponio","sequence":"additional","affiliation":[{"name":"ORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry Complutense University  Madrid Spain"},{"name":"Department of Life Sciences, Health and Health Professions Link Campus University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"de Arriba","sequence":"additional","affiliation":[{"name":"ORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"ORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-0920","authenticated-orcid":false,"given":"Rosa Mar\u00eda","family":"L\u00f3pez\u2010Pintor","sequence":"additional","affiliation":[{"name":"ORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-022-00783-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19084593"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13133354"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-023-01543-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13542"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2024.102779"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12343"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-008-0574-y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-02823-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0303-6987.2002.028.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2024.12.002"},{"key":"e_1_2_9_13_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5","author":"Higgins J. 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