{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:05:53Z","timestamp":1781010353533,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016809","name":"Bureau of Science and Technology Nanchong Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify T1N0M0 oral tongue squamous cell carcinoma (OTSCC) patient subgroups benefiting most from neck dissection (ND) based on the SEER database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with T1N0M0 OTSCC were identified from the SEER database. Propensity score\u2010matching (PSM) was utilized to balance baseline characteristics between ND and non\u2010ND groups. Survival differences between these groups were compared using Kaplan\u2013Meier (K\u2010M) analysis and log\u2010rank tests. Additionally, a multivariable Cox regression model was applied to the pre\u2010matched cohort to identify independent prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 2426 cases were included. In the multivariable model adjusted for key prognosticators, ND was an independent factor associated with significantly improved OS and DSS. After PSM, 1702 well\u2010balanced patients were analyzed. Subgroup analyses based on tumor characteristics revealed that favorable survival outcomes associated with ND were predominantly observed in patients with tumor sizes 11\u201320\u2009mm and those with moderate or poor\/undifferentiated differentiation. For patients with small tumors (1\u201310\u2009mm) or well\u2010differentiated histology, survival outcomes were comparable between the ND and observation groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ND was associated with improved survival for T1N0M0 OTSCC patients with 11\u201320\u2009mm tumors and moderate\/poor\/undifferentiated differentiation. For patients with smaller tumors (1\u201310\u2009mm) or well\u2010differentiated histology, the observation strategy had demonstrated survival benefits comparable to ND.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70170","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T06:35:36Z","timestamp":1766730936000},"page":"1018-1030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Do Patients With\n                    <scp>T1N0M0<\/scp>\n                    Oral Tongue Squamous Cell Carcinoma (\n                    <scp>OTSCC<\/scp>\n                    ) Need Neck Dissection? A Study Based on\n                    <scp>SEER<\/scp>\n                    Database"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0576-7874","authenticated-orcid":false,"given":"Zongyi","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Beijing Anzhen Nanchong Hospital, Capital Medical University &amp; Nanchong Central Hospital  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Affiliated Hospital of North Sichuan Medical College  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Ming","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Beijing Anzhen Nanchong Hospital, Capital Medical University &amp; Nanchong Central Hospital  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Beijing Anzhen Nanchong Hospital, Capital Medical University &amp; Nanchong Central Hospital  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7179-6600","authenticated-orcid":false,"given":"Xiaoyao","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Beijing Anzhen Nanchong Hospital, Capital Medical University &amp; Nanchong Central Hospital  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998221101191"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-025-05694-z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04437-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2023.4049"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14352"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2025.104672"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2024.102146"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03541-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2023.01.036"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.15484"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001578"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85647-y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.7083"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.106808"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-024-02923-0"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2021.01.042"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27786"},{"issue":"12","key":"e_1_2_10_19_1","article-title":"Interventions for the Treatment of Oral Cavity and Oropharyngeal Cancer: Chemotherapy","volume":"12","author":"Parmar A.","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-04172-2"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-08310-0"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998221098011"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-024-05514-8"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj11010006"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01106"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00729"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.106273"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.109480"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7016"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-2210"},{"issue":"8","key":"e_1_2_10_31_1","first-page":"CD006205","article-title":"Interventions for the Treatment of Oral Cavity and Oropharyngeal Cancers: Surgical Treatment","volume":"8","author":"Worthington H. 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