{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:42:26Z","timestamp":1790113346501,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["N01AG62101"],"award-info":[{"award-number":["N01AG62101"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["N01AG62103"],"award-info":[{"award-number":["N01AG62103"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["N01AG62106"],"award-info":[{"award-number":["N01AG62106"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG028050"],"award-info":[{"award-number":["R01AG028050"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate whether periodontal parameters and tooth loss are associated with lung cancer incidence and mortality among older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Data are from the Health, Aging and Body Composition (Health ABC) study, which included 1136 older adults who received a periodontal examination and were followed for up to 16\u2009years. Pocket depth and clinical attachment level were assessed for all present teeth. Adjusted Cox regression models were used to examine the relationship between periodontal parameters and number of natural teeth with lung cancer incidence and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Lung cancer incidence was 4.4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200950) and was identified as cause of death in 3.3% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200938). Those presenting at least 10% of sites with probing depth \u2265\u20096\u2009mm demonstrated a higher risk of lung cancer and death due to lung cancer (hazard ratio [HR]: 3.12, 95% confidence interval [CI]: 1.45\u20136.72 and HR: 3.08, 95% CI: 1.27\u20137.46), respectively. Tooth loss was associated with a reduced hazard of lung cancer incidence (HR: 0.96; 95% CI: 0.93\u20130.99) and related mortality (HR: 0.96; 95% CI: 0.92\u20130.99).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The association between severe periodontal disease parameters and tooth loss with lung cancer among older adults underscores the importance of oral health maintenance for cancer prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70178","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:24:56Z","timestamp":1767587096000},"page":"1460-1470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incident Lung Cancer and Mortality: Data From Health\n                    <scp>ABC<\/scp>\n                    Using Periodontal Status and Tooth Loss"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-4146","authenticated-orcid":false,"given":"Taciane Menezes","family":"da Silveira","sequence":"first","affiliation":[{"name":"Graduate Dentistry Program Universidade Federal de Pelotas  Pelotas Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor M.","family":"Simonsick","sequence":"additional","affiliation":[{"name":"Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging Intramural Research Program  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Balbinot","family":"Hilgert","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Dentistry Universidade Federal do Rio Grande do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Neves","family":"Hugo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Health Promotion New York University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3945-1752","authenticated-orcid":false,"given":"Francisco Wilker Mustafa Gomes","family":"Muniz","sequence":"additional","affiliation":[{"name":"Department of Semiology and Clinic Universidade Federal de Pelotas  Pelotas Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9188-7337","authenticated-orcid":false,"given":"Nat\u00e1lia Marcumini","family":"Pola","sequence":"additional","affiliation":[{"name":"Department of Semiology and Clinic Universidade Federal de Pelotas  Pelotas Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12889\u2010023\u201015529\u20107"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/ANNALS.1999.4.1.1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345221104725"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/PRD.12540"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/CAAC.21492"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/CAAC.21834"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/ANNUREV\u2010PHYSIOL\u2010030212\u2010183653"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5107696"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JGO.2018.07.008"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2188\/JEA.JE20180243"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2010.01.025\/ASSET\/A22FFD83\u20100DE8\u20104033\u2010B7E5\u2010D1315740D575\/MAIN.ASSETS\/GR3.JPG"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3906\/SAG\u20101812\u20108"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201021\u20101059"},{"key":"e_1_2_10_15_1","volume-title":"Cancer Control","author":"IARC","year":"2020"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/CCD.CCD_117_22"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.006"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CRITREVONC.2024.104323"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PMED.1003178"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u201012\u2010385"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31537"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TRANON.2020.100972"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010014\u20100405\u20103"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00359\u20102016"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513490168"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1034\/J.1600\u20100528.2002.00008.X"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/EPIREV\/MXX006"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.14436\/1466\u20102094.25.1.045\u2010058.oar"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/IJE\/DYZ078"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17\u20100721"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/JNCI\/DJR216"},{"key":"e_1_2_10_32_1","unstructured":"Posit Team. 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