{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:05:52Z","timestamp":1784001952806,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate gingival and periodontal characteristics in Ectodermal dysplasia (ED), focusing on soft\u2010tissue phenotype, anatomical variations, and periodontal architecture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Observational clinical study of 11 individuals (16\u201330\u2009years) with confirmed clinical or genetic ED diagnosis. Only periodontally healthy patients were included. Assessments comprised Plaque Index and modified Gingival Index, Probing Depth (PD), Bleeding on Probing (BoP), Gingival Phenotype, Widths of Attached Gingiva (AGW) and Keratinized Mucosa (KMW). A histological sample of keratinized gingiva was obtained from a single patient to complement the clinical evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A consistently thin gingival phenotype was found, with medium\/thick tissues confined to isolated molars. AGW and KMW were within ranges but unevenly distributed; several mandibular areas showed reduced or absent attached gingiva. Some sites with minimal AGW lacked recession, suggesting a congenital condition. Gingival fragility and translucency complicated standard indices, potentially overestimating PD and BoP. Histology showed epithelial projections into the submucosa and poorly organized connective tissue with loosely arranged collagen and loss of normal supracrestal orientation. Scattered epithelial nests and ectopic enamel matrix deposits are visible within the submucosa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Individuals with ED may exhibit soft\u2010tissue features and periodontal architecture distinct from typical patterns, supporting the need for tailored clinical assessment and potentially modified diagnostic criteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70196","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T04:29:29Z","timestamp":1767932969000},"page":"1451-1459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periodontal Architecture in Ectodermal Dysplasia: An Observational Clinical and Histological Study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7312-802X","authenticated-orcid":false,"given":"Marco","family":"Montevecchi","sequence":"first","affiliation":[{"name":"Division of Periodontology and Implantology, Department of Biomedical and Neuromotor Sciences, School of Dentistry Alma Mater Studiorum \u2013 University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5200-9408","authenticated-orcid":false,"given":"Margherita Giorgia","family":"Liguori","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences University of L'Aquila  L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Santini","sequence":"additional","affiliation":[{"name":"Division of Periodontology and Implantology, Department of Biomedical and Neuromotor Sciences, School of Dentistry Alma Mater Studiorum \u2013 University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola Marco","family":"Sforza","sequence":"additional","affiliation":[{"name":"Private Practice  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6944-6508","authenticated-orcid":false,"given":"Giulia","family":"Querzoli","sequence":"additional","affiliation":[{"name":"Section of Anatomic Pathology S. Orsola Hospital IRCCS Azienda Ospedaliero Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum Universit\u00e0 di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3097-9670","authenticated-orcid":false,"given":"Leoluca","family":"Valeriani","sequence":"additional","affiliation":[{"name":"Division of Periodontology and Implantology, Department of Biomedical and Neuromotor Sciences, School of Dentistry Alma Mater Studiorum \u2013 University of Bologna  Bologna Italy"},{"name":"e\u2010Campus University  Novedrate Como Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"229","article-title":"Problems and Proposals for Recording Gingivitis and Plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1966.37.1.5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-04053-w"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61493"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.4947"},{"key":"e_1_2_11_7_1","first-page":"13","article-title":"Oligodontia Ectodermal Dysplasia: On Signs, Symptoms, Genetics, and Outcomes of Dental Treatment","volume":"205","author":"Bergendal B.","year":"2010","journal-title":"Swedish Dental Journal"},{"key":"e_1_2_11_8_1","first-page":"149","article-title":"Osseointegrated Implants in the Oral Habilitation of a Boy With Ectodermal Dysplasia: A Case Report","volume":"41","author":"Bergendal T.","year":"1991","journal-title":"International Dental Journal"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2011.01732.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.01.037"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1982.53.5.285"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10005-1165"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2012.07.012"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13505"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1981.52.8.420"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1991.0307"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpr.2001.118876"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19\u20100577"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(99)70185-X"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2008.07.014"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01180.x"},{"key":"e_1_2_11_22_1","first-page":"285","article-title":"Hypohidrotic Ectodermal Dysplasia: Characteristics and Treatment","volume":"26","author":"Kupietzky A.","year":"1995","journal-title":"Quintessence International"},{"key":"e_1_2_11_23_1","first-page":"147","article-title":"Implant\u2010Prosthetic Partial\u2010Arch Restoration in a Patient With Ectodermal Dysplasia Characterized by Oligodontia and Localized Bone Deficiency: A Case Report","volume":"24","author":"Lamazza L.","year":"2009","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.10.623"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e31822f7b24"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_11_27_1","volume-title":"Textbook of Periodontia","author":"Miller S. 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